Deoxynivalenol induces apoptosis and disrupts cellular homeostasis through MAPK signaling pathways in bovine mammary epithelial cells

Jin Young Lee, Whasun Lim, Sunwoo Park, Jinyoung Kim, Seungkwon You, Gwonhwa Song

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


Deoxynivalenol (DON), a fungus-derived mycotoxin, also known as vomitoxin, is found in a wide range of cereal grains and grain-based food products. The biological toxicity of DON has been described in various species, but its toxicity and functional effects in mammary epithelial cells are unclear. In this study, we investigated the effect of DON on bovine mammary epithelial (MAC-T) cells using mechanistic approaches. We detected DON-induced cell cycle abrogation and calcium deficiency, leading to apoptotic cell death via MAPK signaling pathways. Moreover, we studied the transcriptional activation of blood and milk junctional regulators as well as inflammatory cytokines in response to DON. The results of this study contribute to a comprehensive understanding of DON-associated toxicity mechanisms in bovine mammary epithelial cells, which may facilitate the enhancement of milk stabilization in parallel with the establishment of safety profiles to protect against DON contamination in livestock farms and in the food industry. Deoxynivalenol contamination induces cell cycle arrest and apoptosis in bovine mammary epithelial cells via MAPK signaling pathways.

Original languageEnglish
Pages (from-to)879-887
Number of pages9
JournalEnvironmental Pollution
Publication statusPublished - 2019 Sept

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute funded by the Ministry of Health and Welfare (grant number: HI17C0929) and the National Research Foundation of Korea (NRF) grant funded by the >Ministry of Science and ICT(MSIT) (grant number: 2018R1C1B6009048).

Publisher Copyright:
© 2019 Elsevier Ltd


  • Apoptosis
  • Cow
  • Deoxynivalenol
  • Mammary
  • Signaling transduction

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis


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