Design and applications of fluorescent detectors for peroxynitrite

Shan Wang; Liyan Chen; Paramesh Jangili; Amit Sharma; Wei Li; Ji Ting Hou; Caiqin Qin; Juyoung Yoon; Jong Seung Kim

doi:10.1016/j.ccr.2018.06.013

Design and applications of fluorescent detectors for peroxynitrite

Shan Wang, Liyan Chen, Paramesh Jangili, Amit Sharma, Wei Li, Ji Ting Hou, Caiqin Qin, Juyoung Yoon, Jong Seung Kim

Research output: Contribution to journal › Review article › peer-review

118 Citations (Scopus)

Abstract

Peroxynitrite (ONOO⁻) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO⁻, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO⁻ and their biological applications in diverse living systems.

Original language	English
Pages (from-to)	36-54
Number of pages	19
Journal	Coordination Chemistry Reviews
Volume	374
DOIs	https://doi.org/10.1016/j.ccr.2018.06.013
Publication status	Published - 2018 Nov 1

Bibliographical note

Funding Information:
J.-T. Hou and C. Qin acknowledge grants from the National Natural Science Foundation of China (no. 31371750 ) and Hubei Provincial Natural Science Foundation ( 2018CFB264 ). J. Yoon and J. S. Kim acknowledge grants from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government ( MSIP ) (No. 2012R1A3A2048814 for J.Y. and 2018R1A3B1052702 for J.S.K.).

Funding Information:
J.-T. Hou and C. Qin acknowledge grants from the National Natural Science Foundation of China (no. 31371750) and Hubei Provincial Natural Science Foundation (2018CFB264). J. Yoon and J. S. Kim acknowledge grants from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and 2018R1A3B1052702 for J.S.K.).

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

Boronic acids or boronates
Fluorescence probes
In vivo imaging
Intracellular imaging
N-dearylation
Peroxynitrite
Reactive oxygen species (ROS)

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.ccr.2018.06.013

Cite this

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title = "Design and applications of fluorescent detectors for peroxynitrite",

abstract = "Peroxynitrite (ONOO−) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO−, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO− and their biological applications in diverse living systems.",

keywords = "Boronic acids or boronates, Fluorescence probes, In vivo imaging, Intracellular imaging, N-dearylation, Peroxynitrite, Reactive oxygen species (ROS)",

author = "Shan Wang and Liyan Chen and Paramesh Jangili and Amit Sharma and Wei Li and Hou, {Ji Ting} and Caiqin Qin and Juyoung Yoon and Kim, {Jong Seung}",

note = "Funding Information: J.-T. Hou and C. Qin acknowledge grants from the National Natural Science Foundation of China (no. 31371750 ) and Hubei Provincial Natural Science Foundation ( 2018CFB264 ). J. Yoon and J. S. Kim acknowledge grants from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government ( MSIP ) (No. 2012R1A3A2048814 for J.Y. and 2018R1A3B1052702 for J.S.K.). Funding Information: J.-T. Hou and C. Qin acknowledge grants from the National Natural Science Foundation of China (no. 31371750) and Hubei Provincial Natural Science Foundation (2018CFB264). J. Yoon and J. S. Kim acknowledge grants from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and 2018R1A3B1052702 for J.S.K.). Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

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doi = "10.1016/j.ccr.2018.06.013",

language = "English",

volume = "374",

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journal = "Coordination Chemistry Reviews",

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AU - Wang, Shan

AU - Chen, Liyan

AU - Jangili, Paramesh

AU - Sharma, Amit

AU - Li, Wei

AU - Hou, Ji Ting

AU - Qin, Caiqin

AU - Yoon, Juyoung

AU - Kim, Jong Seung

N1 - Funding Information: J.-T. Hou and C. Qin acknowledge grants from the National Natural Science Foundation of China (no. 31371750 ) and Hubei Provincial Natural Science Foundation ( 2018CFB264 ). J. Yoon and J. S. Kim acknowledge grants from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government ( MSIP ) (No. 2012R1A3A2048814 for J.Y. and 2018R1A3B1052702 for J.S.K.). Funding Information: J.-T. Hou and C. Qin acknowledge grants from the National Natural Science Foundation of China (no. 31371750) and Hubei Provincial Natural Science Foundation (2018CFB264). J. Yoon and J. S. Kim acknowledge grants from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814 for J.Y. and 2018R1A3B1052702 for J.S.K.). Publisher Copyright: © 2018 Elsevier B.V.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Peroxynitrite (ONOO−) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO−, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO− and their biological applications in diverse living systems.

AB - Peroxynitrite (ONOO−) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO−, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO− and their biological applications in diverse living systems.

KW - Boronic acids or boronates

KW - Fluorescence probes

KW - In vivo imaging

KW - Intracellular imaging

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KW - Reactive oxygen species (ROS)

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DO - 10.1016/j.ccr.2018.06.013

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AN - SCOPUS:85049470499

SN - 0010-8545

VL - 374

SP - 36

EP - 54

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

ER -

Design and applications of fluorescent detectors for peroxynitrite

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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