A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).
|Number of pages||17|
|Publication status||Published - 2000 Mar 1|
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry