Abstract
A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).
Original language | English |
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Pages (from-to) | 1087-1103 |
Number of pages | 17 |
Journal | Heterocycles |
Volume | 52 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2000 Mar 1 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry