Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Sang Sup Jew; Eun Kyung Kim; Sun Mi Je; Long Xuan Zhao; Hyung Ook Kim; Hyeung Geun Park; Kwang Ho Ko; Won Ki Kim; Hwa Jung Kim; Jae Hoon Cheong; Eung Seok Lee

doi:10.3987/COM-98-8235

Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Sang Sup Jew, Eun Kyung Kim, Sun Mi Je, Long Xuan Zhao, Hyung Ook Kim, Hyeung Geun Park, Kwang Ho Ko, Won Ki Kim, Hwa Jung Kim, Jae Hoon Cheong, Eung Seok Lee

Research output: Contribution to journal › Article › peer-review

Abstract

A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

Original language	English
Pages (from-to)	1087-1103
Number of pages	17
Journal	Heterocycles
Volume	52
Issue number	3
DOIs	https://doi.org/10.3987/COM-98-8235
Publication status	Published - 2000 Mar 1
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities",

abstract = "A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).",

author = "Jew, {Sang Sup} and Kim, {Eun Kyung} and Je, {Sun Mi} and Zhao, {Long Xuan} and Kim, {Hyung Ook} and Park, {Hyeung Geun} and Ko, {Kwang Ho} and Kim, {Won Ki} and Kim, {Hwa Jung} and Cheong, {Jae Hoon} and Lee, {Eung Seok}",

year = "2000",

month = mar,

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doi = "10.3987/COM-98-8235",

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journal = "Heterocycles",

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publisher = "Japan Institute of Heterocyclic Chemistry",

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T1 - Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

AU - Jew, Sang Sup

AU - Kim, Eun Kyung

AU - Je, Sun Mi

AU - Zhao, Long Xuan

AU - Kim, Hyung Ook

AU - Park, Hyeung Geun

AU - Ko, Kwang Ho

AU - Kim, Won Ki

AU - Kim, Hwa Jung

AU - Cheong, Jae Hoon

AU - Lee, Eung Seok

PY - 2000/3/1

Y1 - 2000/3/1

N2 - A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

AB - A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

UR - http://www.scopus.com/inward/record.url?scp=0034162704&partnerID=8YFLogxK

U2 - 10.3987/COM-98-8235

DO - 10.3987/COM-98-8235

M3 - Article

AN - SCOPUS:0034162704

SN - 0385-5414

VL - 52

SP - 1087

EP - 1103

JO - Heterocycles

JF - Heterocycles

IS - 3

ER -

Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Abstract

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