Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1

Ha Soon Choi; Zhicheng Wang; Wendy Richmond; Xiaohui He; Kunyong Yang; Tao Jiang; Taebo Sim; Donald Karanewsky; Xiang Ju Gu; Vicki Zhou; Yi Liu; Osamu Ohmori; Jeremy Caldwell; Nathanael Gray; Yun He

doi:10.1016/j.bmcl.2006.01.053

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1

Ha Soon Choi, Zhicheng Wang, Wendy Richmond, Xiaohui He, Kunyong Yang, Tao Jiang, Taebo Sim, Donald Karanewsky, Xiang Ju Gu, Vicki Zhou, Yi Liu, Osamu Ohmori, Jeremy Caldwell, Nathanael Gray, Yun He

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinase inhibitors.

Original language	English
Pages (from-to)	2173-2176
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2006.01.053
Publication status	Published - 2006 Apr 15

Keywords

7H-Pyrrolo[2,3-d]pyrimidines
Focal adhesion kinase
Inhibition
SAR

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2006.01.053

Cite this

Choi, H. S., Wang, Z., Richmond, W., He, X., Yang, K., Jiang, T., Sim, T., Karanewsky, D., Gu, X. J., Zhou, V., Liu, Y., Ohmori, O., Caldwell, J., Gray, N., & He, Y. (2006). Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1. Bioorganic and Medicinal Chemistry Letters, 16(8), 2173-2176. https://doi.org/10.1016/j.bmcl.2006.01.053

@article{b33b05f9ed45487ab7bf2106514e449f,

title = "Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1",

abstract = "A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinase inhibitors.",

keywords = "7H-Pyrrolo[2,3-d]pyrimidines, Focal adhesion kinase, Inhibition, SAR",

author = "Choi, {Ha Soon} and Zhicheng Wang and Wendy Richmond and Xiaohui He and Kunyong Yang and Tao Jiang and Taebo Sim and Donald Karanewsky and Gu, {Xiang Ju} and Vicki Zhou and Yi Liu and Osamu Ohmori and Jeremy Caldwell and Nathanael Gray and Yun He",

year = "2006",

month = apr,

day = "15",

doi = "10.1016/j.bmcl.2006.01.053",

language = "English",

volume = "16",

pages = "2173--2176",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1

AU - Choi, Ha Soon

AU - Wang, Zhicheng

AU - Richmond, Wendy

AU - He, Xiaohui

AU - Yang, Kunyong

AU - Jiang, Tao

AU - Sim, Taebo

AU - Karanewsky, Donald

AU - Gu, Xiang Ju

AU - Zhou, Vicki

AU - Liu, Yi

AU - Ohmori, Osamu

AU - Caldwell, Jeremy

AU - Gray, Nathanael

AU - He, Yun

PY - 2006/4/15

Y1 - 2006/4/15

N2 - A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinase inhibitors.

AB - A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinase inhibitors.

KW - 7H-Pyrrolo[2,3-d]pyrimidines

KW - Focal adhesion kinase

KW - Inhibition

KW - SAR

UR - http://www.scopus.com/inward/record.url?scp=33644798693&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2006.01.053

DO - 10.1016/j.bmcl.2006.01.053

M3 - Article

C2 - 16458503

AN - SCOPUS:33644798693

SN - 0960-894X

VL - 16

SP - 2173

EP - 2176

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this