Design and synthesis of biofunctionalized metallic/magnetic nanomaterials

Eun Kyung Lim; Seungjoo Haam; Kwangyeol Lee; Yong Min Huh

doi:10.1007/978-1-61779-151-2_36

Design and synthesis of biofunctionalized metallic/magnetic nanomaterials

Eun Kyung Lim
, Seungjoo Haam^*
, Kwangyeol Lee
, Yong Min Huh

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Abstract

Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibratingsample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	583-595
Number of pages	13
DOIs	https://doi.org/10.1007/978-1-61779-151-2_36
Publication status	Published - 2011

Publication series

Name	Methods in Molecular Biology
Volume	751
ISSN (Print)	1064-3745

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC 2011.

Keywords

Antibody
Coprecipitation
Drug
Ligand exchange
Magnetic nanocrystals
Magnetic nanoparticles
Microemulsion
Seed-mediated growth

ASJC Scopus subject areas

Molecular Biology
Genetics

Access to Document

10.1007/978-1-61779-151-2_36

Cite this

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title = "Design and synthesis of biofunctionalized metallic/magnetic nanomaterials",

abstract = "Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibratingsample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.",

keywords = "Antibody, Coprecipitation, Drug, Ligand exchange, Magnetic nanocrystals, Magnetic nanoparticles, Microemulsion, Seed-mediated growth",

author = "Lim, \{Eun Kyung\} and Seungjoo Haam and Kwangyeol Lee and Huh, \{Yong Min\}",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC 2011.",

year = "2011",

doi = "10.1007/978-1-61779-151-2\_36",

language = "English",

series = "Methods in Molecular Biology",

publisher = "Humana Press Inc.",

pages = "583--595",

booktitle = "Methods in Molecular Biology",

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TY - CHAP

T1 - Design and synthesis of biofunctionalized metallic/magnetic nanomaterials

AU - Lim, Eun Kyung

AU - Haam, Seungjoo

AU - Lee, Kwangyeol

AU - Huh, Yong Min

N1 - Publisher Copyright: © Springer Science+Business Media, LLC 2011.

PY - 2011

Y1 - 2011

N2 - Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibratingsample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.

AB - Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibratingsample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.

KW - Antibody

KW - Coprecipitation

KW - Drug

KW - Ligand exchange

KW - Magnetic nanocrystals

KW - Magnetic nanoparticles

KW - Microemulsion

KW - Seed-mediated growth

UR - https://www.scopus.com/pages/publications/80053296434

U2 - 10.1007/978-1-61779-151-2_36

DO - 10.1007/978-1-61779-151-2_36

M3 - Chapter

C2 - 21674356

AN - SCOPUS:80053296434

T3 - Methods in Molecular Biology

SP - 583

EP - 595

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Design and synthesis of biofunctionalized metallic/magnetic nanomaterials

Abstract

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Bibliographical note

Keywords

ASJC Scopus subject areas

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