Abstract
A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.
Original language | English |
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Pages (from-to) | 2991-2998 |
Number of pages | 8 |
Journal | Bulletin of the Korean Chemical Society |
Volume | 33 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2012 Sept 20 |
Keywords
- 1,3,4-triarylpyrazole
- A375P
- Anticancer
- Diarylamide
- Diarylurea
ASJC Scopus subject areas
- Chemistry(all)