Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold

Won Kyoung Choi, Mohammed I. El-Gamal, Hong Seok Choi, Jun Hee Hong, Daejin Baek, Kihang Choi, Chang Hyun Oh

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.

    Original languageEnglish
    Pages (from-to)2991-2998
    Number of pages8
    JournalBulletin of the Korean Chemical Society
    Volume33
    Issue number9
    DOIs
    Publication statusPublished - 2012 Sept 20

    Keywords

    • 1,3,4-triarylpyrazole
    • A375P
    • Anticancer
    • Diarylamide
    • Diarylurea

    ASJC Scopus subject areas

    • General Chemistry

    Fingerprint

    Dive into the research topics of 'Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold'. Together they form a unique fingerprint.

    Cite this