Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Yeon Ok Lee, Jung Won Shin, C. Yi, Yun Hak Lee, Nak Won Sohn, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

Original languageEnglish
Pages (from-to)5741-5744
Number of pages4
JournalChemical Communications
Volume50
Issue number43
DOIs
Publication statusPublished - 2014 May 1

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

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