Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Yeon Ok Lee; Jung Won Shin; C. Yi; Yun Hak Lee; Nak Won Sohn; Chulhun Kang; Jong Seung Kim

doi:10.1039/c4cc02011a

Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Yeon Ok Lee, Jung Won Shin, C. Yi, Yun Hak Lee, Nak Won Sohn, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ₄₂-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

Original language	English
Pages (from-to)	5741-5744
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	43
DOIs	https://doi.org/10.1039/c4cc02011a
Publication status	Published - 2014 May 1

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c4cc02011a

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title = "Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe",

abstract = "We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.",

author = "Lee, {Yeon Ok} and Shin, {Jung Won} and C. Yi and Lee, {Yun Hak} and Sohn, {Nak Won} and Chulhun Kang and Kim, {Jong Seung}",

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AU - Lee, Yeon Ok

AU - Shin, Jung Won

AU - Yi, C.

AU - Lee, Yun Hak

AU - Sohn, Nak Won

AU - Kang, Chulhun

AU - Kim, Jong Seung

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AB - We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

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DO - 10.1039/c4cc02011a

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EP - 5744

JO - Chemical Communications

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Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Abstract

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