Detection of genetic alterations in Korean ovarian carcinomas by degenerate oligonucleotide primed polymerase chain reaction-comparative genomic hybridization

Gi Jin Kim; Joo Oh Kim; Eun Kyung Hong; Hyun Kim; Yong Hyuck Chun; Sun-Hwa Park

doi:10.1016/S0165-4608(03)00154-7

Detection of genetic alterations in Korean ovarian carcinomas by degenerate oligonucleotide primed polymerase chain reaction-comparative genomic hybridization

Gi Jin Kim, Joo Oh Kim, Eun Kyung Hong, Hyun Kim, Yong Hyuck Chun, Sun-Hwa Park

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Chromosomal aberrations in 22 Koreans with ovarian carcinomas were investigated by degenerate oligonucleotide primed-polymerase chain reaction comparative genomic hybridization. The common sites of copy number increases were 20q (90%), 17q23∼qter (86%), 8q22∼qter (68%), 3q25∼qter (59%), 6p21 (59%), 11q13 (54%), 16p (40%), 2q31∼qter (36%), 7q (36%), 14q31 (36%), 15q24∼qter (36%), and 1q32∼qter (31%). DNA amplification was identified in 18 carcinomas (82%). The frequent sites of amplification were 20q13.2∼qter, 8q24.1, 17q23∼qter, 3q25∼qter, and 6p21. The most frequent sites of copy number decreases were 4q21∼q31 (54%), 5q13∼q21 (50%), and 13q14∼q21 (45%). The recurrent gains and losses of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes, respectively.

Original language	English
Pages (from-to)	23-27
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	147
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(03)00154-7
Publication status	Published - 2003 Nov

Bibliographical note

Funding Information:
This work was supported by a grant from Medical Science Research Center Korea University and the Brain Korea 21 Project in 2001. We particularly thank Dr. Woong Sun, Department of Anatomy, Korea University College of Medicine, for comments.

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0165-4608(03)00154-7

Cite this

@article{83b066c3921c462786f43367848fe2cb,

title = "Detection of genetic alterations in Korean ovarian carcinomas by degenerate oligonucleotide primed polymerase chain reaction-comparative genomic hybridization",

abstract = "Chromosomal aberrations in 22 Koreans with ovarian carcinomas were investigated by degenerate oligonucleotide primed-polymerase chain reaction comparative genomic hybridization. The common sites of copy number increases were 20q (90%), 17q23∼qter (86%), 8q22∼qter (68%), 3q25∼qter (59%), 6p21 (59%), 11q13 (54%), 16p (40%), 2q31∼qter (36%), 7q (36%), 14q31 (36%), 15q24∼qter (36%), and 1q32∼qter (31%). DNA amplification was identified in 18 carcinomas (82%). The frequent sites of amplification were 20q13.2∼qter, 8q24.1, 17q23∼qter, 3q25∼qter, and 6p21. The most frequent sites of copy number decreases were 4q21∼q31 (54%), 5q13∼q21 (50%), and 13q14∼q21 (45%). The recurrent gains and losses of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes, respectively.",

author = "Kim, {Gi Jin} and Kim, {Joo Oh} and Hong, {Eun Kyung} and Hyun Kim and Chun, {Yong Hyuck} and Sun-Hwa Park",

note = "Funding Information: This work was supported by a grant from Medical Science Research Center Korea University and the Brain Korea 21 Project in 2001. We particularly thank Dr. Woong Sun, Department of Anatomy, Korea University College of Medicine, for comments. ",

year = "2003",

month = nov,

doi = "10.1016/S0165-4608(03)00154-7",

language = "English",

volume = "147",

pages = "23--27",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Detection of genetic alterations in Korean ovarian carcinomas by degenerate oligonucleotide primed polymerase chain reaction-comparative genomic hybridization

AU - Kim, Gi Jin

AU - Kim, Joo Oh

AU - Hong, Eun Kyung

AU - Kim, Hyun

AU - Chun, Yong Hyuck

AU - Park, Sun-Hwa

N1 - Funding Information: This work was supported by a grant from Medical Science Research Center Korea University and the Brain Korea 21 Project in 2001. We particularly thank Dr. Woong Sun, Department of Anatomy, Korea University College of Medicine, for comments.

PY - 2003/11

Y1 - 2003/11

N2 - Chromosomal aberrations in 22 Koreans with ovarian carcinomas were investigated by degenerate oligonucleotide primed-polymerase chain reaction comparative genomic hybridization. The common sites of copy number increases were 20q (90%), 17q23∼qter (86%), 8q22∼qter (68%), 3q25∼qter (59%), 6p21 (59%), 11q13 (54%), 16p (40%), 2q31∼qter (36%), 7q (36%), 14q31 (36%), 15q24∼qter (36%), and 1q32∼qter (31%). DNA amplification was identified in 18 carcinomas (82%). The frequent sites of amplification were 20q13.2∼qter, 8q24.1, 17q23∼qter, 3q25∼qter, and 6p21. The most frequent sites of copy number decreases were 4q21∼q31 (54%), 5q13∼q21 (50%), and 13q14∼q21 (45%). The recurrent gains and losses of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes, respectively.

AB - Chromosomal aberrations in 22 Koreans with ovarian carcinomas were investigated by degenerate oligonucleotide primed-polymerase chain reaction comparative genomic hybridization. The common sites of copy number increases were 20q (90%), 17q23∼qter (86%), 8q22∼qter (68%), 3q25∼qter (59%), 6p21 (59%), 11q13 (54%), 16p (40%), 2q31∼qter (36%), 7q (36%), 14q31 (36%), 15q24∼qter (36%), and 1q32∼qter (31%). DNA amplification was identified in 18 carcinomas (82%). The frequent sites of amplification were 20q13.2∼qter, 8q24.1, 17q23∼qter, 3q25∼qter, and 6p21. The most frequent sites of copy number decreases were 4q21∼q31 (54%), 5q13∼q21 (50%), and 13q14∼q21 (45%). The recurrent gains and losses of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0142248382&partnerID=8YFLogxK

U2 - 10.1016/S0165-4608(03)00154-7

DO - 10.1016/S0165-4608(03)00154-7

M3 - Article

C2 - 14580767

AN - SCOPUS:0142248382

SN - 0165-4608

VL - 147

SP - 23

EP - 27

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Detection of genetic alterations in Korean ovarian carcinomas by degenerate oligonucleotide primed polymerase chain reaction-comparative genomic hybridization

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this