Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea

Jin Sun No; Won keun Kim; Jeong Ah Kim; Seung Ho Lee; Sook Young Lee; Ji Hye Kim; Jeong Hoon Kho; Daesang Lee; Dong Hyun Song; Se Hun Gu; Seong Tae Jeong; Heung Chul Kim; Terry A. Klein; Jin Won Song

doi:10.1111/1348-0421.12370

Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea

Jin Sun No, Won keun Kim, Jeong Ah Kim, Seung Ho Lee, Sook Young Lee, Ji Hye Kim, Jeong Hoon Kho, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Heung Chul Kim, Terry A. Klein, Jin Won Song

Department of Biomedical Sciences

Research output: Contribution to journal › Comment/debate › peer-review

8 Citations (Scopus)

Abstract

Hantaan virus (HTNV), of the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS) in humans. Although the majority of epidemiologic studies have found that rodents are seropositive for hantavirus-specific immunoglobulin, the discovery of hantavirus RNA in seronegative hosts has led to an investigation of the presence of HTNV RNA in rodents captured in HFRS endemic areas. HTNV RNA was detected in seven (3.8%) of 186 anti-HTNV IgG seronegative rodents in Republic of Korea (ROK) during 2013-2014. RT-qPCR for HTNV RNA revealed dynamic virus-host interactions of HTNV in areas of high endemicity, providing important insights into the epidemiology of hantaviruses.

Original language	English
Pages (from-to)	268-271
Number of pages	4
Journal	Microbiology and Immunology
Volume	60
Issue number	4
DOIs	https://doi.org/10.1111/1348-0421.12370
Publication status	Published - 2016 Apr 1

Bibliographical note

Publisher Copyright:
© 2016 The Societies and John Wiley & Sons Australia, Ltd.

Keywords

Epidemiology
Hantaan virus
Virus-host interaction

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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10.1111/1348-0421.12370

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No, J. S., Kim, W. K., Kim, J. A., Lee, S. H., Lee, S. Y., Kim, J. H., Kho, J. H., Lee, D., Song, D. H., Gu, S. H., Jeong, S. T., Kim, H. C., Klein, T. A., & Song, J. W. (2016). Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea. Microbiology and Immunology, 60(4), 268-271. https://doi.org/10.1111/1348-0421.12370

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title = "Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea",

abstract = "Hantaan virus (HTNV), of the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS) in humans. Although the majority of epidemiologic studies have found that rodents are seropositive for hantavirus-specific immunoglobulin, the discovery of hantavirus RNA in seronegative hosts has led to an investigation of the presence of HTNV RNA in rodents captured in HFRS endemic areas. HTNV RNA was detected in seven (3.8%) of 186 anti-HTNV IgG seronegative rodents in Republic of Korea (ROK) during 2013-2014. RT-qPCR for HTNV RNA revealed dynamic virus-host interactions of HTNV in areas of high endemicity, providing important insights into the epidemiology of hantaviruses.",

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author = "No, {Jin Sun} and Kim, {Won keun} and Kim, {Jeong Ah} and Lee, {Seung Ho} and Lee, {Sook Young} and Kim, {Ji Hye} and Kho, {Jeong Hoon} and Daesang Lee and Song, {Dong Hyun} and Gu, {Se Hun} and Jeong, {Seong Tae} and Kim, {Heung Chul} and Klein, {Terry A.} and Song, {Jin Won}",

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year = "2016",

month = apr,

day = "1",

doi = "10.1111/1348-0421.12370",

language = "English",

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AU - No, Jin Sun

AU - Kim, Won keun

AU - Kim, Jeong Ah

AU - Lee, Seung Ho

AU - Lee, Sook Young

AU - Kim, Ji Hye

AU - Kho, Jeong Hoon

AU - Lee, Daesang

AU - Song, Dong Hyun

AU - Gu, Se Hun

AU - Jeong, Seong Tae

AU - Kim, Heung Chul

AU - Klein, Terry A.

AU - Song, Jin Won

PY - 2016/4/1

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N2 - Hantaan virus (HTNV), of the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS) in humans. Although the majority of epidemiologic studies have found that rodents are seropositive for hantavirus-specific immunoglobulin, the discovery of hantavirus RNA in seronegative hosts has led to an investigation of the presence of HTNV RNA in rodents captured in HFRS endemic areas. HTNV RNA was detected in seven (3.8%) of 186 anti-HTNV IgG seronegative rodents in Republic of Korea (ROK) during 2013-2014. RT-qPCR for HTNV RNA revealed dynamic virus-host interactions of HTNV in areas of high endemicity, providing important insights into the epidemiology of hantaviruses.

AB - Hantaan virus (HTNV), of the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS) in humans. Although the majority of epidemiologic studies have found that rodents are seropositive for hantavirus-specific immunoglobulin, the discovery of hantavirus RNA in seronegative hosts has led to an investigation of the presence of HTNV RNA in rodents captured in HFRS endemic areas. HTNV RNA was detected in seven (3.8%) of 186 anti-HTNV IgG seronegative rodents in Republic of Korea (ROK) during 2013-2014. RT-qPCR for HTNV RNA revealed dynamic virus-host interactions of HTNV in areas of high endemicity, providing important insights into the epidemiology of hantaviruses.

KW - Epidemiology

KW - Hantaan virus

KW - Virus-host interaction

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M3 - Comment/debate

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SN - 0385-5600

VL - 60

SP - 268

EP - 271

JO - Microbiology and Immunology

JF - Microbiology and Immunology

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ER -

Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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