Determining correspondence in 3-D MR brain images using attribute vectors as morphological signatures of voxels

Zhong Xue, Dinggang Shen, Christos Davatzikos

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


Finding point correspondence in anatomical images is a key step in shape analysis and deformable registration. This paper proposes an automatic correspondence detection algorithm for intramodality MR brain images of different subjects using wavelet-based attribute vectors (WAVs) denned on every image voxel. The attribute vector (AV) is extracted from the wavelet subimages and reflects the image structure in a large neighborhood around the respective voxel in a multiscale fashion. It plays the role of a morphological signature for each voxel, and our goal is, therefore, to make it distinctive of the respective voxel. Correspondence is then determined from similarities of AVs. By incorporating the prior knowledge of the spatial relationship among voxels, the ability of the proposed algorithm to find anatomical correspondence is further improved. Experiments with MR images of human brains show that the algorithm performs similarly to experts, even for complex cortical structures.

Original languageEnglish
Pages (from-to)1276-1291
Number of pages16
JournalIEEE Transactions on Medical Imaging
Issue number10
Publication statusPublished - 2004 Oct

Bibliographical note

Funding Information:
Manuscript received May 2, 2004; revised June 24, 2004. This work was supported by the National Institutes of Health (NIH) under Grant R01AG14971. The Associate Editor responsible for coordinating the review of this paper and recommending its publication was M. Sonka. Asterisk indicates corresponding author. *Z. Xue is with the Section of Biomedical Image Analysis (SBIA), Department of Radiology School of Medicine, University of Pennsylvania, 3600 Market ST Suite 380, Philadelphia PA 19104 USA (e-mail:


  • Computational anatomy
  • Correspondence
  • Deformable registration
  • Image matching
  • Wavelet transformations

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


Dive into the research topics of 'Determining correspondence in 3-D MR brain images using attribute vectors as morphological signatures of voxels'. Together they form a unique fingerprint.

Cite this