Development and evaluation of a protein microarray chip for diagnosis of hepatitis C virus

Chul Soo Yuk, Ku Lee Hyung, Tae Kim Hee, Keel Choi Yong, Cheon Lee Byung, Bok Hwan Chun, Namhyun Chung

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    A protein chip diagnostic kit was developed for the diagnosis of hepatitis C virus (HCV) based on the protein chip technique and the immuno-concentration method. This kit was designed for low-density protein chips and also for the availability of multiple sample screening. Applicability of the chip was evaluated using 96 blood specimens and the results were compared to results of an anti-HCV enzyme immunoassay (EIA) test. With further development, the technology associated with the development of this chip could be applied to the simultaneous detection of multiple protein-protein, protein-ligand interactions.

    Original languageEnglish
    Pages (from-to)1563-1568
    Number of pages6
    JournalBiotechnology letters
    Volume26
    Issue number20
    DOIs
    Publication statusPublished - 2004 Oct

    Bibliographical note

    Funding Information:
    This work was supported by a Technical Innovation Project of the Small and Medium Business Administration of Korea.

    Keywords

    • Blood testing
    • Hepatitis C virus
    • Immuno-concentration
    • Membrane
    • Microarray
    • Protein array

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Applied Microbiology and Biotechnology

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