Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.
Bibliographical noteFunding Information:
This work was supported by the National Research Council of Science & Technology (NST) grant by the Republic of Korea (No. CRC-15-04-KIST), the Ministry of Health & Welfare, Republic of Korea (No. HI14C3344), the National Medical Research Council grant (NMRC/CBRG/1438/2015), and the Brain Research Program through the National Research Foundation of Korea (NRF) (No. 2016M3C7A1913844).
© The Royal Society of Chemistry.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry