Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

Sungsu Lim; Md Mamunul Haque; Dongdong Su; Dohee Kim; Jun Seok Lee; Young Tae Chang; Yun Kyung Kim

doi:10.1039/c6cc08826k

Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

Sungsu Lim, Md Mamunul Haque, Dongdong Su, Dohee Kim, Jun Seok Lee, Young Tae Chang, Yun Kyung Kim

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.

Original language	English
Pages (from-to)	1607-1610
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	10
DOIs	https://doi.org/10.1039/c6cc08826k
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the National Research Council of Science & Technology (NST) grant by the Republic of Korea (No. CRC-15-04-KIST), the Ministry of Health & Welfare, Republic of Korea (No. HI14C3344), the National Medical Research Council grant (NMRC/CBRG/1438/2015), and the Brain Research Program through the National Research Foundation of Korea (NRF) (No. 2016M3C7A1913844).

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c6cc08826k

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title = "Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells",

abstract = "Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.",

author = "Sungsu Lim and Haque, {Md Mamunul} and Dongdong Su and Dohee Kim and Lee, {Jun Seok} and Chang, {Young Tae} and Kim, {Yun Kyung}",

note = "Funding Information: This work was supported by the National Research Council of Science & Technology (NST) grant by the Republic of Korea (No. CRC-15-04-KIST), the Ministry of Health & Welfare, Republic of Korea (No. HI14C3344), the National Medical Research Council grant (NMRC/CBRG/1438/2015), and the Brain Research Program through the National Research Foundation of Korea (NRF) (No. 2016M3C7A1913844). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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language = "English",

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AU - Lim, Sungsu

AU - Haque, Md Mamunul

AU - Su, Dongdong

AU - Kim, Dohee

AU - Lee, Jun Seok

AU - Chang, Young Tae

AU - Kim, Yun Kyung

N1 - Funding Information: This work was supported by the National Research Council of Science & Technology (NST) grant by the Republic of Korea (No. CRC-15-04-KIST), the Ministry of Health & Welfare, Republic of Korea (No. HI14C3344), the National Medical Research Council grant (NMRC/CBRG/1438/2015), and the Brain Research Program through the National Research Foundation of Korea (NRF) (No. 2016M3C7A1913844). Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.

AB - Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.

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SN - 1359-7345

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SP - 1607

EP - 1610

JO - Chemical Communications

JF - Chemical Communications

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Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

Abstract

Bibliographical note

ASJC Scopus subject areas

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