Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

Sungsu Lim, Md Mamunul Haque, Dongdong Su, Dohee Kim, Jun Seok Lee, Young Tae Chang, Yun Kyung Kim

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.

Original languageEnglish
Pages (from-to)1607-1610
Number of pages4
JournalChemical Communications
Issue number10
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the National Research Council of Science & Technology (NST) grant by the Republic of Korea (No. CRC-15-04-KIST), the Ministry of Health & Welfare, Republic of Korea (No. HI14C3344), the National Medical Research Council grant (NMRC/CBRG/1438/2015), and the Brain Research Program through the National Research Foundation of Korea (NRF) (No. 2016M3C7A1913844).

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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