Abstract
Fibrin glue (FG) has been successfully used in a wide range of surgical fields such as skin graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The sustained release of antibiotics from FG for a longer period is desirable to avoid bacterial infection after application. Ampicillin sodium (AMP-Na) was selected as a model antibiotic and incorporated into FG. The incorporation of AMP-Na was attempted in two different ways. One was incorporation of AMP-Na in a dispersed state with the modification of the preparation method of FG. The other was incorporation of bovine serum albumin microspheres (BSA-MS) containing AMP-Na. The in vitro release of AMP-Na from various FGs and BSA MS was examined. The modifications of FG were found not to be appropriate methods to achieve sustained release of AMP-Na. The incorporation of crosslinked BSA-MS containing AMP-Na into FG was found to reduce the initial rapid lease of AMP-Na and retarded release of AMP-Na.
| Original language | English |
|---|---|
| Pages (from-to) | 65-70 |
| Number of pages | 6 |
| Journal | Journal of Controlled Release |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1996 Mar |
Keywords
- Ampicillin sodium
- Bovine serum albumin
- Fibrin glue
- Microsphere
- Sustained release
ASJC Scopus subject areas
- Pharmaceutical Science