Development of a rectally administrable Dnase1 to treat septic shock by targeting NETs

Keyphrases

• DNase 100%
• Septic Shock 100%
• LPS-induced Inflammation 60%
• Shock 40%
• Mouse Serum 40%
• Neutrophil Extracellular Traps 40%
• Rectal Suppositories 40%
• Amino Acid Residues 20%
• Genetic Engineering 20%
• Survival Rate 20%
• Lifesaving 20%
• Intravenous Administration 20%
• Mouse Model 20%
• Mortality Rate 20%
• Human Neutrophils 20%
• Syrinx 20%
• Hypotension 20%
• Cell-penetrating Peptide 20%
• Log-rank Test 20%
• Shock Model 20%
• Saving Effect 20%
• Systemic Inflammation 20%
• Rectal mucosa 20%
• Cutaneous Vein 20%
• Mouse Rectum 20%
• Rectal Administration 20%
• DNA Threads 20%
• Deoxyribonuclease Activity 20%

Immunology and Microbiology

• Neutrophil Extracellular Traps 100%
• Absorption 50%
• Vein 50%
• Mouse Model 50%
• Survival Rate 50%
• Mortality Rate 50%
• Neutrophil Granulocyte 50%
• Systemic Inflammation 50%
• Rectum 50%
• Rectum Mucosa 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Septic Shock 100%
• Rectal Administration 60%
• Deoxyribonuclease 40%
• Amino Acid 20%
• Inflammation 20%
• Mortality Rate 20%
• Survival Rate 20%
• Mouse Model 20%
• Hypotension 20%
• Cell Penetrating Peptide 20%