Development of a subject-specific guide system for Low-Intensity Focused Ultrasound (LIFU) brain stimulation

Haeyoung Joe; Ki Joo Pahk; Shinsuk Park; Hyungmin Kim

doi:10.1016/j.cmpb.2019.05.001

Development of a subject-specific guide system for Low-Intensity Focused Ultrasound (LIFU) brain stimulation

Haeyoung Joe
, Ki Joo Pahk
, Shinsuk Park
, Hyungmin Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Low-Intensity Focused Ultrasound (LIFU) has recently been considered as a promising neuromodulation technique because it can noninvasively stimulate the brain with a high spatial resolution. As spatial resolution is improved, there is a growing demand for developing more accurate and convenient guide systems. Therefore, in the present study, we have developed and prototyped a 3D printed wearable subject-specific helmet for LIFU stimulation that is guaranteed to be accurate. The spatial relationship between the target position and the full-width at half-maximum (FWHM) of acoustic pressure of the transducer, i.e. focal volume, was compared using the conventional image-guided navigation system. According to the distribution of positional errors, the target position was located well within the focal volume.

Original language	English
Pages (from-to)	105-110
Number of pages	6
Journal	Computer Methods and Programs in Biomedicine
Volume	176
DOIs	https://doi.org/10.1016/j.cmpb.2019.05.001
Publication status	Published - 2019 Jul

Bibliographical note

Funding Information:
This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning ( 2015M3C7A1064833 ).

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

Brain stimulation
Image-guided navigation
Low-intensity focused ultrasound
Subject-specific helmet

ASJC Scopus subject areas

Software
Computer Science Applications
Health Informatics

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10.1016/j.cmpb.2019.05.001

Cite this

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title = "Development of a subject-specific guide system for Low-Intensity Focused Ultrasound (LIFU) brain stimulation",

abstract = "Low-Intensity Focused Ultrasound (LIFU) has recently been considered as a promising neuromodulation technique because it can noninvasively stimulate the brain with a high spatial resolution. As spatial resolution is improved, there is a growing demand for developing more accurate and convenient guide systems. Therefore, in the present study, we have developed and prototyped a 3D printed wearable subject-specific helmet for LIFU stimulation that is guaranteed to be accurate. The spatial relationship between the target position and the full-width at half-maximum (FWHM) of acoustic pressure of the transducer, i.e. focal volume, was compared using the conventional image-guided navigation system. According to the distribution of positional errors, the target position was located well within the focal volume.",

keywords = "Brain stimulation, Image-guided navigation, Low-intensity focused ultrasound, Subject-specific helmet",

author = "Haeyoung Joe and Pahk, \{Ki Joo\} and Shinsuk Park and Hyungmin Kim",

note = "Funding Information: This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT \& Future Planning ( 2015M3C7A1064833 ). Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

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doi = "10.1016/j.cmpb.2019.05.001",

language = "English",

volume = "176",

pages = "105--110",

journal = "Computer Methods and Programs in Biomedicine",

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AU - Joe, Haeyoung

AU - Pahk, Ki Joo

AU - Park, Shinsuk

AU - Kim, Hyungmin

N1 - Funding Information: This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning ( 2015M3C7A1064833 ). Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/7

Y1 - 2019/7

N2 - Low-Intensity Focused Ultrasound (LIFU) has recently been considered as a promising neuromodulation technique because it can noninvasively stimulate the brain with a high spatial resolution. As spatial resolution is improved, there is a growing demand for developing more accurate and convenient guide systems. Therefore, in the present study, we have developed and prototyped a 3D printed wearable subject-specific helmet for LIFU stimulation that is guaranteed to be accurate. The spatial relationship between the target position and the full-width at half-maximum (FWHM) of acoustic pressure of the transducer, i.e. focal volume, was compared using the conventional image-guided navigation system. According to the distribution of positional errors, the target position was located well within the focal volume.

AB - Low-Intensity Focused Ultrasound (LIFU) has recently been considered as a promising neuromodulation technique because it can noninvasively stimulate the brain with a high spatial resolution. As spatial resolution is improved, there is a growing demand for developing more accurate and convenient guide systems. Therefore, in the present study, we have developed and prototyped a 3D printed wearable subject-specific helmet for LIFU stimulation that is guaranteed to be accurate. The spatial relationship between the target position and the full-width at half-maximum (FWHM) of acoustic pressure of the transducer, i.e. focal volume, was compared using the conventional image-guided navigation system. According to the distribution of positional errors, the target position was located well within the focal volume.

KW - Brain stimulation

KW - Image-guided navigation

KW - Low-intensity focused ultrasound

KW - Subject-specific helmet

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DO - 10.1016/j.cmpb.2019.05.001

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JO - Computer Methods and Programs in Biomedicine

JF - Computer Methods and Programs in Biomedicine

ER -

Development of a subject-specific guide system for Low-Intensity Focused Ultrasound (LIFU) brain stimulation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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