Development of a theranostic prodrug for colon cancer therapy by combining ligand-targeted delivery and enzyme-stimulated activation

Amit Sharma, Eun Joong Kim, Hu Shi, Jin Yong Lee, Bong Geun Chung, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

The high incidence of colorectal cancer worldwide is currently a major health concern. Although conventional chemotherapy and surgery are effective to some extent, there is always a risk of relapse due to associated side effects, including post-surgical complications and non-discrimination between cancer and normal cells. In this study, we developed a small molecule-based theranostic system, Gal-Dox, which is preferentially taken up by colon cancer cells through receptor-mediated endocytosis. After cancer-specific activation, the active drug Dox (doxorubicin) is released with a fluorescence turn-on response, allowing both drug localization and site of action to be monitored. The therapeutic potency of Gal-Dox was also evaluated, both in vivo and ex vivo, thus illustrating the potential of Gal-Dox as a colorectal cancer theranostic with great specificity.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalBiomaterials
Volume155
DOIs
Publication statusPublished - 2018 Feb

Bibliographical note

Funding Information:
This research was supported by the CRI project (No. 2009-0081566 , J.S.K.) and the Bio & Medical Technology Development Program (No. 2015M3A9D7030461 , B.G.C.) of the National Research Foundation funded by the Ministry of Science, ICT and Future Planning of Korea .

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

  • Colon cancer
  • Doxorubicin
  • Targeted drug delivery
  • Theranostic
  • β-Galactosidase

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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