Abstract
In vitro models for neurologic diseases have been highly demanded for better understanding of pathology and strategies for treatment of the diseases such as Alzheimer's disease (AD); however, there have been limits in mimicking in vivo microenvironment on in vitro system. Here, we have developed a microfluidic chip based on three-dimensional (3D) neurospheroids providing interstitial level of flow mimicking in vivo microenvironment more closely. With this platform, we investigated the effect of flow on neurospheroids in size, neural networking, and neural differentiation. Also, we observed the effect of amyloid-β (Aβ) which is generally accepted as a major component causing AD.
| Original language | English |
|---|---|
| Title of host publication | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 2524-2525 |
| Number of pages | 2 |
| ISBN (Print) | 9780979806476 |
| Publication status | Published - 2014 |
| Event | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 2014 Oct 26 → 2014 Oct 30 |
Other
| Other | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
|---|---|
| Country/Territory | United States |
| City | San Antonio |
| Period | 14/10/26 → 14/10/30 |
Keywords
- Alzheimer's disease
- Brain-on-a-chip
- Interstitial flow
- Neurospheroid
ASJC Scopus subject areas
- Control and Systems Engineering