Development of a three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

J. S. Park, B. K. Lee, G. S. Jeong, C. J. Lee, S. H. Lee

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    In vitro models for neurologic diseases have been highly demanded for better understanding of pathology and strategies for treatment of the diseases such as Alzheimer's disease (AD); however, there have been limits in mimicking in vivo microenvironment on in vitro system. Here, we have developed a microfluidic chip based on three-dimensional (3D) neurospheroids providing interstitial level of flow mimicking in vivo microenvironment more closely. With this platform, we investigated the effect of flow on neurospheroids in size, neural networking, and neural differentiation. Also, we observed the effect of amyloid-β (Aβ) which is generally accepted as a major component causing AD.

    Original languageEnglish
    Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
    PublisherChemical and Biological Microsystems Society
    Pages2524-2525
    Number of pages2
    ISBN (Electronic)9780979806476
    Publication statusPublished - 2014
    Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
    Duration: 2014 Oct 262014 Oct 30

    Publication series

    Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

    Other

    Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
    Country/TerritoryUnited States
    CitySan Antonio
    Period14/10/2614/10/30

    Bibliographical note

    Publisher Copyright:
    © 14CBMS.

    Keywords

    • Alzheimer's disease
    • Brain-on-a-chip
    • Interstitial flow
    • Neurospheroid

    ASJC Scopus subject areas

    • Control and Systems Engineering

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