Development of an algorithm to regulate pump output for a closed air-loop type pneumatic biventricular assist device

Kyoung Won Nam, Jung Joo Lee, Chang Mo Hwang, Jaesoon Choi, Hyuk Choi, Seong Wook Choi, Kyung Sun

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The closed air space-type of extracorporeal pneumatic ventricular assist device (VAD) developed by the Korea Artificial Organ Center utilizes a bellows-transforming mechanism to generate the air pressure required to pump blood. This operating mechanism can reduce the size and weight of the driving unit; however, the output of the blood pump can be affected by the pressure loading conditions of the blood sac. Therefore, to guarantee a proper pump output level, regardless of the pressure loading conditions that vary over time, automatic pump output regulation of the blood pump is required. We describe herein a pump output regulation algorithm that was developed to maintain pump output around a reference level against various afterload pressures, and verified the pump performance in vitro. Based on actual operating conditions in animal experiments, the pumping rate was limited to 40-84 beats per minute, and the afterload pressure was limited to 80-150 mm Hg. The tested reference pump output was 4.0 L/min. During experiments, the pump output was successfully and automatically regulated within the preset area regardless of the varying afterload conditions. The results of this preliminary experiment can be used as the basis for an automatic control algorithm that can enhance the stability and reliability of the applied VAD.

Original languageEnglish
Pages (from-to)1063-1068
Number of pages6
JournalArtificial Organs
Issue number12
Publication statusPublished - 2009 Dec


  • Afterload pressure estimation
  • Pneumatic ventricular assist device
  • Pump output estimation
  • Pump output regulation

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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