Development of ATP-competitive mTOR inhibitors

Keyphrases

• Mammalian Target of Rapamycin (mTOR) 100%
• MTOR Inhibitor 100%
• ATP-competitive 100%
• Rapalogs 66%
• Antitumor Efficacy 33%
• Cell-based 33%
• Rapamycin 33%
• Signal Transduction Pathway 33%
• Metabolic Disease 33%
• Cancer Types 33%
• Clinical Efficacy 33%
• Clinical Development 33%
• Torin1 33%
• Development Effort 33%
• Medium Throughput 33%
• Cancer Disease 33%
• Structure-based Drug Design 33%
• Screening Assays 33%
• MTOR Complex 2 (mTORC2) 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Adenosine Triphosphate 100%
• Mammalian Target of Rapamycin Inhibitor 100%
• Malignant Neoplasm 66%
• Mammalian Target of Rapamycin 66%
• Anticarcinogen 33%
• Metabolic Disorder 33%
• Rapamycin 33%
• Drug Development 33%
• Mammalian Target of Rapamycin Complex 1 33%
• Mammalian Target of Rapamycin Complex 2 33%

Biochemistry, Genetics and Molecular Biology

• Mechanistic Target of Rapamycin 100%
• Adenosine Triphosphate 100%
• Mammalian Target of Rapamycin Complex 1 20%
• Mammalian Target of Rapamycin Complex 2 20%