Development of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management

Sun Young Wang, Hyosuk Kim, Gijung Kwak, Hong Yeol Yoon, Sung Duk Jo, Ji Eun Lee, Daeho Cho, Ick Chan Kwon, Sun Hwa Kim

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


In the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. In particular, wound-healing peptides (WHPs) and peptide-grafted dressings hold great promise for novel therapeutic strategies for wound management. This study reports a topical formulation of a new synthetic WHP (REGRT, REG) embedded in a hyaluronic acid (HA)-based hydrogel dressing for the enhancement of acute excisional wound repair. The copper-free click chemistry is utilized to form biocompatible HA hydrogels by cross-linking dibenzocyclooctyl-functionalized HA with 4-arm poly(ethylene glycol) (PEG) azide. The HA hydrogels are grafted with the REG peptide, a functional derivative of erythroid differentiation regulator1, displaying potent cell motility-stimulating ability, thus sustainably releasing physiologically active peptides for a prolonged period. Combined with the traditional wound healing benefits of HA, the HA hydrogel embedded REG (REG-HAgel) accelerates re-epithelialization in skin wound healing, particularly by promoting migration of fibroblasts, keratinocytes, and endothelial cells. REG-HAgels improve not only rate, but quality of wound healing with higher collagen deposition and more microvascular formation while being nontoxic. The peptide-grafted HA hydrogel system can be considered as a promising new wound dressing formulation strategy for the treatment of different types of wounds with combinations of various natural and synthetic WHPs.

Original languageEnglish
Article number1800852
JournalAdvanced Science
Issue number11
Publication statusPublished - 2018 Nov

Bibliographical note

Funding Information:
This study was supported by Creative Materials Discovery Program (Grant No. 2016M3D1A1021392) through the National Research Foundation (NRF) of Korea and the Intramuarl Research Program of Korea Institute of Scienc and Technology (KIST).

Publisher Copyright:
© 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • bioorthogonal copper free click chemistry
  • peptide-grafted hyaluronic acid hydrogels
  • would healing peptides
  • wound repair

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Chemical Engineering
  • General Materials Science
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • General Engineering
  • General Physics and Astronomy


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