Development of Co-hemin MOF/chitosan composite based biosensor for rapid detection of lactose

Han Suk Choi; Xiaoguang Yang; Guicheng Liu; Dong Sup Kim; Ji Hyun Yang; Ju Hun Lee; Sung Ok Han; Jinyoung Lee; Seung Wook Kim

doi:10.1016/j.jtice.2020.07.021

Development of Co-hemin MOF/chitosan composite based biosensor for rapid detection of lactose

Han Suk Choi, Xiaoguang Yang, Guicheng Liu, Dong Sup Kim, Ji Hyun Yang, Ju Hun Lee, Sung Ok Han, Jinyoung Lee, Seung Wook Kim

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

An electrochemical biosensor containing Co-hemin metal organic frameworks (Co-hemin MOF)/chitosan composite and cellobiose dehydrogenase (CDH) was developed for lactose dectection. The formation of the Co-hemin MOF was verified by scanning electron microscopy, Fourier transform infrared spectroscopy, UV–vis absorption spectroscopy and electrochemical techniques. The Co-hemin MOF/chitosan composite exhibited outstanding electrochemical performance on lactose detection with high sensitivity (102.3 μA mM⁻¹ cm⁻²) and fast response (5 s). More importantly, the lower determination limit of 4 mM and the broad linear ranges of 10 to 100 mM were obtained to detect lactose. With broad linear ranges, the feasibility of dairy application of the biosensor based on Co-hemin MOF electrode was demonstrated in this study.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Journal of the Taiwan Institute of Chemical Engineers
Volume	113
DOIs	https://doi.org/10.1016/j.jtice.2020.07.021
Publication status	Published - 2020 Aug

Bibliographical note

Publisher Copyright:
© 2020 Taiwan Institute of Chemical Engineers

Keywords

Cellobiose dehydrogenase
Co-hemin
Electrochemical biosensor
Lactose
Metal organic frameworks

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1016/j.jtice.2020.07.021

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title = "Development of Co-hemin MOF/chitosan composite based biosensor for rapid detection of lactose",

abstract = "An electrochemical biosensor containing Co-hemin metal organic frameworks (Co-hemin MOF)/chitosan composite and cellobiose dehydrogenase (CDH) was developed for lactose dectection. The formation of the Co-hemin MOF was verified by scanning electron microscopy, Fourier transform infrared spectroscopy, UV–vis absorption spectroscopy and electrochemical techniques. The Co-hemin MOF/chitosan composite exhibited outstanding electrochemical performance on lactose detection with high sensitivity (102.3 μA mM−1 cm−2) and fast response (5 s). More importantly, the lower determination limit of 4 mM and the broad linear ranges of 10 to 100 mM were obtained to detect lactose. With broad linear ranges, the feasibility of dairy application of the biosensor based on Co-hemin MOF electrode was demonstrated in this study.",

keywords = "Cellobiose dehydrogenase, Co-hemin, Electrochemical biosensor, Lactose, Metal organic frameworks",

author = "Choi, {Han Suk} and Xiaoguang Yang and Guicheng Liu and Kim, {Dong Sup} and Yang, {Ji Hyun} and Lee, {Ju Hun} and Han, {Sung Ok} and Jinyoung Lee and Kim, {Seung Wook}",

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year = "2020",

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doi = "10.1016/j.jtice.2020.07.021",

language = "English",

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AU - Choi, Han Suk

AU - Yang, Xiaoguang

AU - Liu, Guicheng

AU - Kim, Dong Sup

AU - Yang, Ji Hyun

AU - Lee, Ju Hun

AU - Han, Sung Ok

AU - Lee, Jinyoung

AU - Kim, Seung Wook

PY - 2020/8

Y1 - 2020/8

N2 - An electrochemical biosensor containing Co-hemin metal organic frameworks (Co-hemin MOF)/chitosan composite and cellobiose dehydrogenase (CDH) was developed for lactose dectection. The formation of the Co-hemin MOF was verified by scanning electron microscopy, Fourier transform infrared spectroscopy, UV–vis absorption spectroscopy and electrochemical techniques. The Co-hemin MOF/chitosan composite exhibited outstanding electrochemical performance on lactose detection with high sensitivity (102.3 μA mM−1 cm−2) and fast response (5 s). More importantly, the lower determination limit of 4 mM and the broad linear ranges of 10 to 100 mM were obtained to detect lactose. With broad linear ranges, the feasibility of dairy application of the biosensor based on Co-hemin MOF electrode was demonstrated in this study.

AB - An electrochemical biosensor containing Co-hemin metal organic frameworks (Co-hemin MOF)/chitosan composite and cellobiose dehydrogenase (CDH) was developed for lactose dectection. The formation of the Co-hemin MOF was verified by scanning electron microscopy, Fourier transform infrared spectroscopy, UV–vis absorption spectroscopy and electrochemical techniques. The Co-hemin MOF/chitosan composite exhibited outstanding electrochemical performance on lactose detection with high sensitivity (102.3 μA mM−1 cm−2) and fast response (5 s). More importantly, the lower determination limit of 4 mM and the broad linear ranges of 10 to 100 mM were obtained to detect lactose. With broad linear ranges, the feasibility of dairy application of the biosensor based on Co-hemin MOF electrode was demonstrated in this study.

KW - Cellobiose dehydrogenase

KW - Co-hemin

KW - Electrochemical biosensor

KW - Lactose

KW - Metal organic frameworks

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SP - 1

EP - 7

JO - Journal of the Taiwan Institute of Chemical Engineers

JF - Journal of the Taiwan Institute of Chemical Engineers

ER -

Development of Co-hemin MOF/chitosan composite based biosensor for rapid detection of lactose

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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