Development of cortical anatomical properties from early childhood to early adulthood

Jingxin Nie; Gang Li; Dinggang Shen

doi:10.1016/j.neuroimage.2013.03.021

Development of cortical anatomical properties from early childhood to early adulthood

Jingxin Nie, Gang Li, Dinggang Shen

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Human brain matures in temporal and regional heterogeneity, with some areas matured at early adulthood. In this study, the relationship of cortical structural developments between different cortical sheet regions is systematically analyzed using interregional correlation coefficient and network methods. Specifically, 951 longitudinal T1 brain MR images from 445 healthy subjects with ages from 3 to 20. years old are used. The result shows that the development of cortex reaches a turning point at around 7. years of age: a) the cortical thickness reaches its highest value and also the cortical folding becomes stable at this age; b) both global and local efficiencies of anatomical correlation networks reach the lowest and highest values at this age, respectively; and c) the change of anatomical correlation networks reach the highest level at this age, and the convergence of different anatomical correlation networks starts to decrease from this age. These results might inspire more studies on why there exists a turning point at this age from different viewpoints. For example, is there any change of synaptic pruning, or is it related to the starting of school life? And how can we benefit from this in the real life?

Original language	English
Pages (from-to)	216-224
Number of pages	9
Journal	NeuroImage
Volume	76
DOIs	https://doi.org/10.1016/j.neuroimage.2013.03.021
Publication status	Published - 2013 Aug 1

Bibliographical note

Funding Information:
This work was supported in part by NIH grants EB008374 , EB006733 , AG041721 and EB009634 .

Funding Information:
Data used in the preparation of this article were obtained from the Pediatric MRI Data Repository created by the NIH MRI Study of Normal Brain Development. This is a multi-site, longitudinal study of typically developing children, from ages newborn through young adulthood, conducted by the Brain Development Cooperative Group and supported by the National Institute of Child Health and Human Development , the National Institute on Drug Abuse , the National Institute of Mental Health , and the National Institute of Neurological Disorders and Stroke (Contract #s N01-HD02-3343 , N01-MH9-0002 , and N01-NS-9-2314 , -2315 , -2316 , -2317 , -2319 and -2320 ). A listing of the participating sites and a complete listing of the study investigators can be found at http://www.bic.mni.mcgill.ca/nihpd/info/participating_centers.html . This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH.

Keywords

Anatomical network
Cortex development
Cortical folding
Cortical thickness

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuroimage.2013.03.021

Cite this

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title = "Development of cortical anatomical properties from early childhood to early adulthood",

abstract = "Human brain matures in temporal and regional heterogeneity, with some areas matured at early adulthood. In this study, the relationship of cortical structural developments between different cortical sheet regions is systematically analyzed using interregional correlation coefficient and network methods. Specifically, 951 longitudinal T1 brain MR images from 445 healthy subjects with ages from 3 to 20. years old are used. The result shows that the development of cortex reaches a turning point at around 7. years of age: a) the cortical thickness reaches its highest value and also the cortical folding becomes stable at this age; b) both global and local efficiencies of anatomical correlation networks reach the lowest and highest values at this age, respectively; and c) the change of anatomical correlation networks reach the highest level at this age, and the convergence of different anatomical correlation networks starts to decrease from this age. These results might inspire more studies on why there exists a turning point at this age from different viewpoints. For example, is there any change of synaptic pruning, or is it related to the starting of school life? And how can we benefit from this in the real life?",

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note = "Funding Information: This work was supported in part by NIH grants EB008374 , EB006733 , AG041721 and EB009634 . Funding Information: Data used in the preparation of this article were obtained from the Pediatric MRI Data Repository created by the NIH MRI Study of Normal Brain Development. This is a multi-site, longitudinal study of typically developing children, from ages newborn through young adulthood, conducted by the Brain Development Cooperative Group and supported by the National Institute of Child Health and Human Development , the National Institute on Drug Abuse , the National Institute of Mental Health , and the National Institute of Neurological Disorders and Stroke (Contract #s N01-HD02-3343 , N01-MH9-0002 , and N01-NS-9-2314 , -2315 , -2316 , -2317 , -2319 and -2320 ). A listing of the participating sites and a complete listing of the study investigators can be found at http://www.bic.mni.mcgill.ca/nihpd/info/participating_centers.html . This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH. ",

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AU - Shen, Dinggang

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Y1 - 2013/8/1

N2 - Human brain matures in temporal and regional heterogeneity, with some areas matured at early adulthood. In this study, the relationship of cortical structural developments between different cortical sheet regions is systematically analyzed using interregional correlation coefficient and network methods. Specifically, 951 longitudinal T1 brain MR images from 445 healthy subjects with ages from 3 to 20. years old are used. The result shows that the development of cortex reaches a turning point at around 7. years of age: a) the cortical thickness reaches its highest value and also the cortical folding becomes stable at this age; b) both global and local efficiencies of anatomical correlation networks reach the lowest and highest values at this age, respectively; and c) the change of anatomical correlation networks reach the highest level at this age, and the convergence of different anatomical correlation networks starts to decrease from this age. These results might inspire more studies on why there exists a turning point at this age from different viewpoints. For example, is there any change of synaptic pruning, or is it related to the starting of school life? And how can we benefit from this in the real life?

AB - Human brain matures in temporal and regional heterogeneity, with some areas matured at early adulthood. In this study, the relationship of cortical structural developments between different cortical sheet regions is systematically analyzed using interregional correlation coefficient and network methods. Specifically, 951 longitudinal T1 brain MR images from 445 healthy subjects with ages from 3 to 20. years old are used. The result shows that the development of cortex reaches a turning point at around 7. years of age: a) the cortical thickness reaches its highest value and also the cortical folding becomes stable at this age; b) both global and local efficiencies of anatomical correlation networks reach the lowest and highest values at this age, respectively; and c) the change of anatomical correlation networks reach the highest level at this age, and the convergence of different anatomical correlation networks starts to decrease from this age. These results might inspire more studies on why there exists a turning point at this age from different viewpoints. For example, is there any change of synaptic pruning, or is it related to the starting of school life? And how can we benefit from this in the real life?

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Development of cortical anatomical properties from early childhood to early adulthood

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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