Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy

Keunsoo Jeong, Chi Soo Kang, Youngsun Kim, Yong Deok Lee, Ick Chan Kwon, Sehoon Kim

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)


Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.

Original languageEnglish
Pages (from-to)31-43
Number of pages13
JournalCancer letters
Issue number1
Publication statusPublished - 2016 Apr 28

Bibliographical note

Funding Information:
This work was supported by the grants from the National Research Foundation of Korea (No. 2014M3A9E5073316 , 2014M3C1A3054141 ), the Korea Health Industry Development Institute (No. HI15C1540 ), and the Intramural Research Program of KIST .

Publisher Copyright:
© 2016 Elsevier Ireland Ltd.


  • Cancer therapy
  • Combination therapy
  • Drug delivery
  • Nanocarrier
  • Stimuli-activated therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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