Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy

Keunsoo Jeong; Chi Soo Kang; Youngsun Kim; Yong Deok Lee; Ick Chan Kwon; Sehoon Kim

doi:10.1016/j.canlet.2016.01.050

Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy

Keunsoo Jeong
, Chi Soo Kang
, Youngsun Kim
, Yong Deok Lee
, Ick Chan Kwon
, Sehoon Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

63 Citations (Scopus)

Abstract

Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.

Original language	English
Pages (from-to)	31-43
Number of pages	13
Journal	Cancer letters
Volume	374
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2016.01.050
Publication status	Published - 2016 Apr 28

Bibliographical note

Funding Information:
This work was supported by the grants from the National Research Foundation of Korea (No. 2014M3A9E5073316 , 2014M3C1A3054141 ), the Korea Health Industry Development Institute (No. HI15C1540 ), and the Intramural Research Program of KIST .

Publisher Copyright:
© 2016 Elsevier Ireland Ltd.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer therapy
Combination therapy
Drug delivery
Nanocarrier
Stimuli-activated therapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2016.01.050

Cite this

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title = "Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy",

abstract = "Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.",

keywords = "Cancer therapy, Combination therapy, Drug delivery, Nanocarrier, Stimuli-activated therapy",

author = "Keunsoo Jeong and Kang, \{Chi Soo\} and Youngsun Kim and Lee, \{Yong Deok\} and Kwon, \{Ick Chan\} and Sehoon Kim",

note = "Funding Information: This work was supported by the grants from the National Research Foundation of Korea (No. 2014M3A9E5073316 , 2014M3C1A3054141 ), the Korea Health Industry Development Institute (No. HI15C1540 ), and the Intramural Research Program of KIST . Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd.",

year = "2016",

month = apr,

day = "28",

doi = "10.1016/j.canlet.2016.01.050",

language = "English",

volume = "374",

pages = "31--43",

journal = "Cancer letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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T1 - Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy

AU - Jeong, Keunsoo

AU - Kang, Chi Soo

AU - Kim, Youngsun

AU - Lee, Yong Deok

AU - Kwon, Ick Chan

AU - Kim, Sehoon

N1 - Funding Information: This work was supported by the grants from the National Research Foundation of Korea (No. 2014M3A9E5073316 , 2014M3C1A3054141 ), the Korea Health Industry Development Institute (No. HI15C1540 ), and the Intramural Research Program of KIST . Publisher Copyright: © 2016 Elsevier Ireland Ltd.

PY - 2016/4/28

Y1 - 2016/4/28

N2 - Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.

AB - Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.

KW - Cancer therapy

KW - Combination therapy

KW - Drug delivery

KW - Nanocarrier

KW - Stimuli-activated therapy

UR - https://www.scopus.com/pages/publications/84959432172

U2 - 10.1016/j.canlet.2016.01.050

DO - 10.1016/j.canlet.2016.01.050

M3 - Review article

C2 - 26854717

AN - SCOPUS:84959432172

SN - 0304-3835

VL - 374

SP - 31

EP - 43

JO - Cancer letters

JF - Cancer letters

IS - 1

ER -

Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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