Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer

S. Chung; J. Park; Y. Lee; C. Chung; D. C. Han; J. K. Chang

doi:10.1109/MMB.2002.1002388

Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer

S. Chung, J. Park, Y. Lee, C. Chung, D. C. Han, J. K. Chang

School of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

The relation between erythrocyte deformability and cancer has been proved in medical fields, but it is very difficult to systemize and commercialize the traditional schemes for erythrocyte deformability assessment. In this work, a desk-top type RBC Hemocytometer system with PDMS microchip has been developed for the assessment. Macrochannels with microfiltering structure in the microchip make the erythrocyte deformed, and with an UV optical array system and C language based image processing software, filter-pass-shape and filter-pass-velocity of erythrocytes are sequentially analyzed. In the comparative studies with blood from cancerous patients and control blood, we could obtain statistically acceptable data that can distinguish cancerous from control regardless of the cancer infected regions. To enhance the performance of the system, comparative studies changing the materials of the chip (silicon-glass, PDMS and PMMA) and sectional surface characteristics control have been accomplished with notable results. This RBC Hemocytometer system can be applied as a practical diagnostic apparatus in early detection of cancer.

Original language	English
Title of host publication	2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	496-499
Number of pages	4
ISBN (Print)	0780374800, 9780780374805
DOIs	https://doi.org/10.1109/MMB.2002.1002388
Publication status	Published - 2002
Event	2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Madison, United States Duration: 2002 May 2 → 2002 May 4

Other

Other	2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology
Country/Territory	United States
City	Madison
Period	02/5/2 → 02/5/4

Keywords

cancer detection
diagnostic device
erythrocyte
PDMS microchip

ASJC Scopus subject areas

Biotechnology
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/MMB.2002.1002388

Cite this

Chung, S., Park, J., Lee, Y., Chung, C., Han, D. C., & Chang, J. K. (2002). Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. In 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings (pp. 496-499). Article 1002388 Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MMB.2002.1002388

Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. / Chung, S.; Park, J.; Lee, Y. et al.
2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2002. p. 496-499 1002388.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chung, S, Park, J, Lee, Y, Chung, C, Han, DC & Chang, JK 2002, Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. in 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings., 1002388, Institute of Electrical and Electronics Engineers Inc., pp. 496-499, 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Madison, United States, 02/5/2. https://doi.org/10.1109/MMB.2002.1002388

Chung S, Park J, Lee Y, Chung C, Han DC, Chang JK. Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer. In 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2002. p. 496-499. 1002388 doi: 10.1109/MMB.2002.1002388

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AB - The relation between erythrocyte deformability and cancer has been proved in medical fields, but it is very difficult to systemize and commercialize the traditional schemes for erythrocyte deformability assessment. In this work, a desk-top type RBC Hemocytometer system with PDMS microchip has been developed for the assessment. Macrochannels with microfiltering structure in the microchip make the erythrocyte deformed, and with an UV optical array system and C language based image processing software, filter-pass-shape and filter-pass-velocity of erythrocytes are sequentially analyzed. In the comparative studies with blood from cancerous patients and control blood, we could obtain statistically acceptable data that can distinguish cancerous from control regardless of the cancer infected regions. To enhance the performance of the system, comparative studies changing the materials of the chip (silicon-glass, PDMS and PMMA) and sectional surface characteristics control have been accomplished with notable results. This RBC Hemocytometer system can be applied as a practical diagnostic apparatus in early detection of cancer.

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KW - erythrocyte

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Development of micro Hemocytometer for human erythrocyte analysis for the early detection of cancer

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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