Abstract
The relation between erythrocyte deformability and cancer has been proved in medical fields, but it is very difficult to systemize and commercialize the traditional schemes for erythrocyte deformability assessment. In this work, a desk-top type RBC Hemocytometer system with PDMS microchip has been developed for the assessment. Macrochannels with microfiltering structure in the microchip make the erythrocyte deformed, and with an UV optical array system and C language based image processing software, filter-pass-shape and filter-pass-velocity of erythrocytes are sequentially analyzed. In the comparative studies with blood from cancerous patients and control blood, we could obtain statistically acceptable data that can distinguish cancerous from control regardless of the cancer infected regions. To enhance the performance of the system, comparative studies changing the materials of the chip (silicon-glass, PDMS and PMMA) and sectional surface characteristics control have been accomplished with notable results. This RBC Hemocytometer system can be applied as a practical diagnostic apparatus in early detection of cancer.
Original language | English |
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Title of host publication | 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 496-499 |
Number of pages | 4 |
ISBN (Print) | 0780374800, 9780780374805 |
DOIs | |
Publication status | Published - 2002 |
Event | 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Madison, United States Duration: 2002 May 2 → 2002 May 4 |
Other
Other | 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology |
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Country/Territory | United States |
City | Madison |
Period | 02/5/2 → 02/5/4 |
Keywords
- cancer detection
- diagnostic device
- erythrocyte
- PDMS microchip
ASJC Scopus subject areas
- Biotechnology
- Microbiology (medical)