Development of microfluidic chip-based alginate microtube for angiogenesis

S. J. Shin; K. H. Lee; S. H. Lee

Development of microfluidic chip-based alginate microtube for angiogenesis

S. J. Shin
, K. H. Lee
, S. H. Lee

Research output: Contribution to conference › Paper › peer-review

Abstract

In this work, we fabricated the microfluidic chip-based micro-alginate tubes (MAT) for angiogenesis. These micro-alginate tubes could be adjusted in selfdeveloping extracellular matrix (ECM)-like networks. We have used poly(dimethylsiloxane) (PDMS) microfluidic device integrated capillary glass pipette as apparatus for micro-alginate tube generation. In addition, we evaluated the micro-alginate tube as an angiogenesis by loading calf pulmonary artery endothelial (CPAE) cells during the fabrication MHT process. From the LIVE/DEAD assay, CPAE cells survived well during the 5 days in vitro. The microfluidic chip-based micro-alginate tube, including cells or proteins, can be produced effective 3-D shaped micro-vascular for the angiogenesis.

Original language	English
Pages	525-527
Number of pages	3
Publication status	Published - 2008
Event	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: 2008 Oct 12 → 2008 Oct 16

Other

Other	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/Territory	United States
City	San Diego, CA
Period	08/10/12 → 08/10/16

Keywords

Alginate
Angiogenesis
Microtube

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

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title = "Development of microfluidic chip-based alginate microtube for angiogenesis",

abstract = "In this work, we fabricated the microfluidic chip-based micro-alginate tubes (MAT) for angiogenesis. These micro-alginate tubes could be adjusted in selfdeveloping extracellular matrix (ECM)-like networks. We have used poly(dimethylsiloxane) (PDMS) microfluidic device integrated capillary glass pipette as apparatus for micro-alginate tube generation. In addition, we evaluated the micro-alginate tube as an angiogenesis by loading calf pulmonary artery endothelial (CPAE) cells during the fabrication MHT process. From the LIVE/DEAD assay, CPAE cells survived well during the 5 days in vitro. The microfluidic chip-based micro-alginate tube, including cells or proteins, can be produced effective 3-D shaped micro-vascular for the angiogenesis.",

keywords = "Alginate, Angiogenesis, Microtube",

author = "Shin, \{S. J.\} and Lee, \{K. H.\} and Lee, \{S. H.\}",

year = "2008",

language = "English",

pages = "525--527",

note = "12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 ; Conference date: 12-10-2008 Through 16-10-2008",

}

TY - CONF

T1 - Development of microfluidic chip-based alginate microtube for angiogenesis

AU - Shin, S. J.

AU - Lee, K. H.

AU - Lee, S. H.

PY - 2008

Y1 - 2008

N2 - In this work, we fabricated the microfluidic chip-based micro-alginate tubes (MAT) for angiogenesis. These micro-alginate tubes could be adjusted in selfdeveloping extracellular matrix (ECM)-like networks. We have used poly(dimethylsiloxane) (PDMS) microfluidic device integrated capillary glass pipette as apparatus for micro-alginate tube generation. In addition, we evaluated the micro-alginate tube as an angiogenesis by loading calf pulmonary artery endothelial (CPAE) cells during the fabrication MHT process. From the LIVE/DEAD assay, CPAE cells survived well during the 5 days in vitro. The microfluidic chip-based micro-alginate tube, including cells or proteins, can be produced effective 3-D shaped micro-vascular for the angiogenesis.

AB - In this work, we fabricated the microfluidic chip-based micro-alginate tubes (MAT) for angiogenesis. These micro-alginate tubes could be adjusted in selfdeveloping extracellular matrix (ECM)-like networks. We have used poly(dimethylsiloxane) (PDMS) microfluidic device integrated capillary glass pipette as apparatus for micro-alginate tube generation. In addition, we evaluated the micro-alginate tube as an angiogenesis by loading calf pulmonary artery endothelial (CPAE) cells during the fabrication MHT process. From the LIVE/DEAD assay, CPAE cells survived well during the 5 days in vitro. The microfluidic chip-based micro-alginate tube, including cells or proteins, can be produced effective 3-D shaped micro-vascular for the angiogenesis.

KW - Alginate

KW - Angiogenesis

KW - Microtube

UR - https://www.scopus.com/pages/publications/84902519499

M3 - Paper

AN - SCOPUS:84902519499

SP - 525

EP - 527

T2 - 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008

Y2 - 12 October 2008 through 16 October 2008

ER -

Development of microfluidic chip-based alginate microtube for angiogenesis

Abstract

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Keywords

ASJC Scopus subject areas

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