Development of Neuroimaging-Based Biomarkers in Major Depression

Kyu Man Han, Byung Joo Ham, Yong Ku Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)


A leading goal in the field of biological psychiatry for depression is to find a promising diagnostic biomarker and selection of specific psychiatric treatment mode that is most likely to benefit patients with depression. Recent neuroimaging studies have characterized the pathophysiology of major depressive disorder (MDD) with functional and structural alterations in the neural circuitry involved in emotion or reward processing. Particularly, structural and functional magnetic resonance imaging (MRI) studies have reported that the brain structures deeply involved in emotion regulation or reward processing including the amygdala, prefrontal cortex (PFC), anterior cingulate cortex (ACC), ventral striatum, and hippocampus are key regions that provide useful information about diagnosis and treatment outcome prediction in MDD. For example, it has been consistently reported that elevated activity of the ACC is associated with better antidepressant response in patients with MDD. This chapter will discuss a growing body of evidence that suggests that diagnosis or prediction of outcome for specific treatment can be assisted by a neuroimaging-based biomarker in MDD.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages15
Publication statusPublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Publisher Copyright:
© 2021, Springer Nature Singapore Pte Ltd.


  • Emotion regulation
  • Magnetic resonance imaging (MRI)
  • Major depressive disorder
  • Neural circuit
  • Reward processing
  • Treatment outcome

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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