Abstract
To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing–dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.
Original language | English |
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Pages (from-to) | 272-281 |
Number of pages | 10 |
Journal | Frontiers of Materials Science |
Volume | 9 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2015 Sept 27 |
Keywords
- chitosan fiber
- liquor absorptivity
- part dissolvability
- surface N-succinylation
- wound dressing
ASJC Scopus subject areas
- Materials Science(all)