Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing

Guohui Sun; Chao Feng; Ming Kong; Xiaojie Cheng; Jiaojiao Bing; Guixue Xia; Zixian Bao; Hyunjin Park; Xiguang Chen

doi:10.1007/s11706-015-0303-y

Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing

Guohui Sun, Chao Feng, Ming Kong, Xiaojie Cheng, Jiaojiao Bing, Guixue Xia, Zixian Bao, Hyunjin Park, Xiguang Chen

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing–dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.

Original language	English
Pages (from-to)	272-281
Number of pages	10
Journal	Frontiers of Materials Science
Volume	9
Issue number	3
DOIs	https://doi.org/10.1007/s11706-015-0303-y
Publication status	Published - 2015 Sept 27

Bibliographical note

Publisher Copyright:
© 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg.

Keywords

chitosan fiber
liquor absorptivity
part dissolvability
surface N-succinylation
wound dressing

ASJC Scopus subject areas

Materials Science(all)

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10.1007/s11706-015-0303-y

Cite this

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title = "Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing",

abstract = "To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing–dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.",

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author = "Guohui Sun and Chao Feng and Ming Kong and Xiaojie Cheng and Jiaojiao Bing and Guixue Xia and Zixian Bao and Hyunjin Park and Xiguang Chen",

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AU - Sun, Guohui

AU - Feng, Chao

AU - Kong, Ming

AU - Cheng, Xiaojie

AU - Bing, Jiaojiao

AU - Xia, Guixue

AU - Bao, Zixian

AU - Park, Hyunjin

AU - Chen, Xiguang

PY - 2015/9/27

Y1 - 2015/9/27

N2 - To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing–dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.

AB - To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing–dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.

KW - chitosan fiber

KW - liquor absorptivity

KW - part dissolvability

KW - surface N-succinylation

KW - wound dressing

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DO - 10.1007/s11706-015-0303-y

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VL - 9

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EP - 281

JO - Frontiers of Materials Science

JF - Frontiers of Materials Science

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ER -

Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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