Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing

Guohui Sun, Chao Feng, Ming Kong, Xiaojie Cheng, Jiaojiao Bing, Guixue Xia, Zixian Bao, Hyunjin Park, Xiguang Chen

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing–dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.

    Original languageEnglish
    Pages (from-to)272-281
    Number of pages10
    JournalFrontiers of Materials Science
    Volume9
    Issue number3
    DOIs
    Publication statusPublished - 2015 Sept 27

    Bibliographical note

    Publisher Copyright:
    © 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg.

    Keywords

    • chitosan fiber
    • liquor absorptivity
    • part dissolvability
    • surface N-succinylation
    • wound dressing

    ASJC Scopus subject areas

    • General Materials Science

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