Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells: A novel mechanism of dexamethasone-induced hematoprotection

Hyongbum Kim, Ji Young Choi, Jung Min Lee, Yoon Shin Park, Hwal Suh, Hae Ryong Song, Sangmee Ahn Jo, Inho Jo

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Angiopoietin-1 (Ang-1) is known to have hematoprotective effects by increasing the quiescence of hematopoietic stem cells. However, it remains to be determined if the upregulation of Ang-1 and the subsequent increase in the quiescence of hematopoietic stem cells are also involved in the dexamethasone (Dex)-mediated bone marrow protection. Here Western blotting and flow cytometric analyses demonstrate that Dex increases the levels of Ang-1 in mouse bone marrow and the quiescence of hematopoietic stem cells. Our data for the first time suggest that the increased quiescence of hematopoietic stem cells provides a novel mechanism of Dex-induced hematoprotection.

Original languageEnglish
Pages (from-to)3509-3514
Number of pages6
JournalFEBS Letters
Volume582
Issue number23-24
DOIs
Publication statusPublished - 2008 Oct 15

Bibliographical note

Funding Information:
We thank Dr. Peter Oettgen (Beth Israel Deaconess Medical Center, Boston, MA) for providing Ang-1 promoter and Dr. Fumio Arai (Keio University, Tokyo, Japan) for technical support regarding the flow cytometry. This work was in part supported by Korean NIH Intramural Grant and the BK project from the Korean Research Foundation Grant funded by the Korean Government (MOEST).

Keywords

  • Angiopoietin-1
  • Bone marrow
  • Dexamethasone
  • Hematopoietic stem cells
  • Hematoprotection

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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