Abstract
We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. X2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyms sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.
Original language | English |
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Pages (from-to) | 125-132 |
Number of pages | 8 |
Journal | Brain Research |
Volume | 824 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1999 Apr 3 |
Externally published | Yes |
Keywords
- Activator protein-1
- Dextromethorphan
- Fos-related antigen
- Hippocampus
- Kainic acid
- Neuroprotection
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology