Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid

Hyoung Chun Kim; Guoying Bing; Wang Kee Jhoo; Kwang Ho Ko; Won Ki Kim; Dong Chul Lee; Eun Jhoo Shin; Jau Shyong Hong

doi:10.1016/S0006-8993(99)01155-5

Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid

Hyoung Chun Kim, Guoying Bing, Wang Kee Jhoo, Kwang Ho Ko, Won Ki Kim, Dong Chul Lee, Eun Jhoo Shin, Jau Shyong Hong

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. X2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyms sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.

Original language	English
Pages (from-to)	125-132
Number of pages	8
Journal	Brain Research
Volume	824
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(99)01155-5
Publication status	Published - 1999 Apr 3
Externally published	Yes

Keywords

Activator protein-1
Dextromethorphan
Fos-related antigen
Hippocampus
Kainic acid
Neuroprotection

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)01155-5

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title = "Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid",

abstract = "We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. X2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyms sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.",

keywords = "Activator protein-1, Dextromethorphan, Fos-related antigen, Hippocampus, Kainic acid, Neuroprotection",

author = "Kim, {Hyoung Chun} and Guoying Bing and Jhoo, {Wang Kee} and Ko, {Kwang Ho} and Kim, {Won Ki} and Lee, {Dong Chul} and Shin, {Eun Jhoo} and Hong, {Jau Shyong}",

note = "Funding Information: We would like to thank Dr. Jerome L. Maderdrut (Tulane University, New Orleans, LA) for his critical reading of this manuscript. This study was supported by the Korea Science and Engineering Foundation (KOSEF 981-0714-107-2).",

year = "1999",

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doi = "10.1016/S0006-8993(99)01155-5",

language = "English",

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AU - Kim, Hyoung Chun

AU - Bing, Guoying

AU - Jhoo, Wang Kee

AU - Ko, Kwang Ho

AU - Kim, Won Ki

AU - Lee, Dong Chul

AU - Shin, Eun Jhoo

AU - Hong, Jau Shyong

N1 - Funding Information: We would like to thank Dr. Jerome L. Maderdrut (Tulane University, New Orleans, LA) for his critical reading of this manuscript. This study was supported by the Korea Science and Engineering Foundation (KOSEF 981-0714-107-2).

PY - 1999/4/3

Y1 - 1999/4/3

N2 - We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. X2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyms sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.

AB - We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. X2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyms sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.

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KW - Dextromethorphan

KW - Fos-related antigen

KW - Hippocampus

KW - Kainic acid

KW - Neuroprotection

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SN - 0006-8993

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Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid

Abstract

Keywords

ASJC Scopus subject areas

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