TY - JOUR
T1 - Di- and Triterpenoids from the Leaves of Casearia balansae and Neurite Outgrowth Promoting Effects of PC12 Cells
AU - Xu, Jing
AU - Kang, Jing
AU - Sun, Xiaocong
AU - Cao, Xiangrong
AU - Rena, Kasimu
AU - Lee, Dongho
AU - Ren, Quanhui
AU - Li, Shen
AU - Ohizumi, Yasushi
AU - Guo, Yuanqiang
N1 - Funding Information:
This research was financially supported by the National Natural Science Foundation of China (No. 21372125).
Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.
PY - 2016/1/22
Y1 - 2016/1/22
N2 - A bioassay-guided phytochemical investigation of the leaves of Casearia balansae led to the isolation of six new cucurbitane-type triterpenoid derivatives (balanterpenes A-F, 1-6) and four new clerdoane-type diterpenoids (balanterpenes G-J, 7-10). The structures of 1-10 were established on the basis of extensive analysis of NMR spectroscopic data, X-ray crystallography, and experimental and calculated electronic circular dichroism spectra. Compound 1 features a ring-expanded triterpenoid skeleton with the C-19 methyl involved in the ring formation, compound 6 possesses a rare hexanortriterpenoid scaffold, and compounds 7-10 may be four new diterpenoid artifacts presumably formed during the extraction and purification processes. Compounds 3 and 7-10 showed promoting effects on neurite outgrowth of PC12 cells with EC50 values in the range 2.9-10.0 μM.
AB - A bioassay-guided phytochemical investigation of the leaves of Casearia balansae led to the isolation of six new cucurbitane-type triterpenoid derivatives (balanterpenes A-F, 1-6) and four new clerdoane-type diterpenoids (balanterpenes G-J, 7-10). The structures of 1-10 were established on the basis of extensive analysis of NMR spectroscopic data, X-ray crystallography, and experimental and calculated electronic circular dichroism spectra. Compound 1 features a ring-expanded triterpenoid skeleton with the C-19 methyl involved in the ring formation, compound 6 possesses a rare hexanortriterpenoid scaffold, and compounds 7-10 may be four new diterpenoid artifacts presumably formed during the extraction and purification processes. Compounds 3 and 7-10 showed promoting effects on neurite outgrowth of PC12 cells with EC50 values in the range 2.9-10.0 μM.
UR - http://www.scopus.com/inward/record.url?scp=84956738170&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.5b00815
DO - 10.1021/acs.jnatprod.5b00815
M3 - Article
C2 - 26699618
AN - SCOPUS:84956738170
SN - 0163-3864
VL - 79
SP - 170
EP - 179
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 1
ER -