Diagnosis and treatment of latent tuberculosis infection

Seung Heon Lee

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)


A small number of viable tuberculosis bacilli can reside in an individual with latent tuberculosis infection (LTBI) without obvious clinical symptoms or abnormal chest radiographs. Diagnosis and treatment for LTBI are important for tuberculosis (TB) control in public and private health, especially in high-risk populations. The updated 2014 Korean guidelines for TB recommend that tuberculin skin tests, interferon-gamma release assays, or a combination of the two can be used for LTBI diagnosis according to age and immune status of the host as well as TB contact history. The regimens for LTBI treatment include isoniazid, rifampicin, or isoniazid/rifampicin. However, results of drug susceptibility test from the index case must be considered in selecting the appropriate drug for recent contacts. Standardized LTBI diagnosis and treatment based on the new 2014 guidelines will contribute to the effective TB control in Korea as well as to the establishment of updated guidelines.

Original languageEnglish
Pages (from-to)56-63
Number of pages8
JournalTuberculosis and Respiratory Diseases
Issue number2
Publication statusPublished - 2015 Apr 1
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2015 The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.


  • Interferon-gamma release assay
  • Latent tuberculosis
  • Tuberculin test

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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