Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2

Hong Jun Kim; Sanghee Kang; Dae Yeoung Kim; Sanguan You; Daeho Park; Sang Cheul Oh; Dae Hee Lee

doi:10.1016/j.fct.2019.01.023

Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2

Hong Jun Kim, Sanghee Kang, Dae Yeoung Kim, Sanguan You, Daeho Park, Sang Cheul Oh, Dae Hee Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Ever since several targeted agents were introduced a decade ago, progress in new therapeutic strategies for colorectal cancer (CRC) has been much slower than that for other cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is widely known to induce cellular apoptosis in numerous cancer cell types. However, many cancer cells are resistant to the effects of TRAIL, and thus, approaches are needed to overcome TRAIL resistance. We demonstrated that non-cytotoxic doses of diallyl disulfide (DADS) increased TRAIL-associated cell death in CRC cell lines. Additionally, synergistic effects between DADS and TRAIL were validated in vivo in nude mice. One process involved in these effects includes down-regulation of the anti-apoptotic protein Bcl-2, and the synergistic effect of DADS with TRAIL was attenuated in Bcl-2-over-expressing cells. Taken together, the results of this study give new insights into the role of DADS in TRAIL-related repression of CRC progression by inhibition of Bcl-2.

Original language	English
Pages (from-to)	354-360
Number of pages	7
Journal	Food and Chemical Toxicology
Volume	125
DOIs	https://doi.org/10.1016/j.fct.2019.01.023
Publication status	Published - 2019 Mar

Keywords

Bcl-2
Death receptor 5
Diallyl disulphide
TRAIL-Resistance

ASJC Scopus subject areas

Food Science
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fct.2019.01.023

Cite this

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title = "Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2",

abstract = "Ever since several targeted agents were introduced a decade ago, progress in new therapeutic strategies for colorectal cancer (CRC) has been much slower than that for other cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is widely known to induce cellular apoptosis in numerous cancer cell types. However, many cancer cells are resistant to the effects of TRAIL, and thus, approaches are needed to overcome TRAIL resistance. We demonstrated that non-cytotoxic doses of diallyl disulfide (DADS) increased TRAIL-associated cell death in CRC cell lines. Additionally, synergistic effects between DADS and TRAIL were validated in vivo in nude mice. One process involved in these effects includes down-regulation of the anti-apoptotic protein Bcl-2, and the synergistic effect of DADS with TRAIL was attenuated in Bcl-2-over-expressing cells. Taken together, the results of this study give new insights into the role of DADS in TRAIL-related repression of CRC progression by inhibition of Bcl-2.",

keywords = "Bcl-2, Death receptor 5, Diallyl disulphide, TRAIL-Resistance",

author = "Kim, {Hong Jun} and Sanghee Kang and Kim, {Dae Yeoung} and Sanguan You and Daeho Park and Oh, {Sang Cheul} and Lee, {Dae Hee}",

note = "Funding Information: This work was supported by a National Research Foundation of Korea grant funded by the Korean government (MSIP) [ 2018R1A6A1A03023584 ] and supported by the Business for Cooperative R & D between Industry , Avicenna Research Institute funded Korea Small and Medium Business Administration in 20 ( C0566291 ) and a Korea University Grant. Funding Information: This work was supported by a National Research Foundation of Korea grant funded by the Korean government (MSIP) [2018R1A6A1A03023584] and supported by the Business for Cooperative R & D between Industry, Avicenna Research Institute funded Korea Small and Medium Business Administration in 20 (C0566291) and a Korea University Grant. Publisher Copyright: {\textcopyright} 2019",

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language = "English",

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T1 - Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2

AU - Kim, Hong Jun

AU - Kang, Sanghee

AU - Kim, Dae Yeoung

AU - You, Sanguan

AU - Park, Daeho

AU - Oh, Sang Cheul

AU - Lee, Dae Hee

N1 - Funding Information: This work was supported by a National Research Foundation of Korea grant funded by the Korean government (MSIP) [ 2018R1A6A1A03023584 ] and supported by the Business for Cooperative R & D between Industry , Avicenna Research Institute funded Korea Small and Medium Business Administration in 20 ( C0566291 ) and a Korea University Grant. Funding Information: This work was supported by a National Research Foundation of Korea grant funded by the Korean government (MSIP) [2018R1A6A1A03023584] and supported by the Business for Cooperative R & D between Industry, Avicenna Research Institute funded Korea Small and Medium Business Administration in 20 (C0566291) and a Korea University Grant. Publisher Copyright: © 2019

PY - 2019/3

Y1 - 2019/3

N2 - Ever since several targeted agents were introduced a decade ago, progress in new therapeutic strategies for colorectal cancer (CRC) has been much slower than that for other cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is widely known to induce cellular apoptosis in numerous cancer cell types. However, many cancer cells are resistant to the effects of TRAIL, and thus, approaches are needed to overcome TRAIL resistance. We demonstrated that non-cytotoxic doses of diallyl disulfide (DADS) increased TRAIL-associated cell death in CRC cell lines. Additionally, synergistic effects between DADS and TRAIL were validated in vivo in nude mice. One process involved in these effects includes down-regulation of the anti-apoptotic protein Bcl-2, and the synergistic effect of DADS with TRAIL was attenuated in Bcl-2-over-expressing cells. Taken together, the results of this study give new insights into the role of DADS in TRAIL-related repression of CRC progression by inhibition of Bcl-2.

AB - Ever since several targeted agents were introduced a decade ago, progress in new therapeutic strategies for colorectal cancer (CRC) has been much slower than that for other cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is widely known to induce cellular apoptosis in numerous cancer cell types. However, many cancer cells are resistant to the effects of TRAIL, and thus, approaches are needed to overcome TRAIL resistance. We demonstrated that non-cytotoxic doses of diallyl disulfide (DADS) increased TRAIL-associated cell death in CRC cell lines. Additionally, synergistic effects between DADS and TRAIL were validated in vivo in nude mice. One process involved in these effects includes down-regulation of the anti-apoptotic protein Bcl-2, and the synergistic effect of DADS with TRAIL was attenuated in Bcl-2-over-expressing cells. Taken together, the results of this study give new insights into the role of DADS in TRAIL-related repression of CRC progression by inhibition of Bcl-2.

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Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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