Dietary galacto-oligosaccharides improve skin health: A randomized double blind clinical trial

Yang Hee Hong, Un Jae Chang, Young Suk Kim, Eun Young Jung, Hyung Joo Suh

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Background and Objectives: To study the effects of galacto-oligosaccharides (GOS) on the skin, we investigated skin-related parameters in healthy adults who received GOS for 12 weeks. Methods and Study Design: This double-blind, randomized, placebo-controlled study included subjects divided into two groups (control and GOS) by stratified block randomization. The GOS group received 1.0 g of GOS twice a day, whereas the control group received only vehicle. Results: The results showed that the increase in corneometer values from baseline to week 12 was significantly greater in the GOS group than in the control group (6.91 vs 2.88 arbitrary units, p < 0.05). The transepidermal water loss (TEWL) in the GOS group was reduced significantly after 12 weeks of GOS treatment (20.1 g/h/m2 at baseline vs 17.5 g/h/m2 at week 12, p < 0.05). The differences in total and percentage of wrinkle areas between the two groups were statistically significant after 12 weeks of GOS treatment (p < 0.05). Conclusion: Our findings support that oral treatment with GOS is beneficial to the skin and present the possibility of new nutritional strategies for skin care.

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalAsia Pacific Journal of Clinical Nutrition
Issue number4
Publication statusPublished - 2017 Jun 1


  • Galacto-oligosaccharide
  • Prebiotics
  • Probiotics
  • Skin hydration
  • Wrinkle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Medicine
  • Nutrition and Dietetics


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