Difference in Carotid Intima-Media Thickness Between Korean and Japanese Men

Jina Choo; Hirotsugu Ueshima; Yangsoo Jang; Kim Sutton-Tyrrell; Aiman El-Saed; Takashi Kadowaki; Tomoko Takamiya; Tomonori Okamura; Yoshiki Ueno; Yasuyuki Nakamura; Akira Sekikawa; J. David Curb; Lewis H. Kuller; Chol Shin

doi:10.1016/j.annepidem.2007.08.002

Difference in Carotid Intima-Media Thickness Between Korean and Japanese Men

Jina Choo, Hirotsugu Ueshima, Yangsoo Jang, Kim Sutton-Tyrrell, Aiman El-Saed, Takashi Kadowaki, Tomoko Takamiya, Tomonori Okamura, Yoshiki Ueno, Yasuyuki Nakamura, Akira Sekikawa, J. David Curb, Lewis H. Kuller, Chol Shin

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Purpose: Koreans are recently at higher risk for coronary heart disease than are the Japanese. We aimed to evaluate levels of carotid intima-media thickness (IMT) and coronary risk factors in Korean and Japanese men in the post-World War II birth cohort. Methods: We conducted a population-based study of 352 randomly selected healthy men 40 to 49 years of age: 102 Koreans in Ansan City, Gyeonggi-do, Korea and 250 Japanese in Kusatsu City, Shiga, Japan. Imaging carotid IMT by ultrasonography and other procedures were standardized. Analyzing blood samples and reading carotid IMT were performed at the University of Pittsburgh. Results: Despite more favorable or similar features in coronary risk factors as compared to Japanese men, the Korean men had a higher crude IMT level than the Japanese men (mean ± standard error, 0.655 ± 0.008 mm vs 0.616 ± 0.005 mm, respectively, p < 0.0001). The difference in the levels of carotid IMT significantly remained after adjusting for metabolic and conventional risk factors (0.654 ± 0.008 mm vs. 0.616 ± 0.005 mm, respectively; p < 0.0001). Conclusions: Among men 40 to 49 years of age, Koreans had significantly higher levels of carotid IMT than the Japanese. Factors that underlie the different susceptibility to subclinical atherosclerosis need to be explored.

Original language	English
Pages (from-to)	310-315
Number of pages	6
Journal	Annals of Epidemiology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.annepidem.2007.08.002
Publication status	Published - 2008 Apr

Bibliographical note

Funding Information:
This research was supported by grants from the National Heart Lung and Blood Institute (R01 HL68200), the Central Research Development at the University of Pittsburgh, the Japanese Ministry of Education, Culture, Sports, Science and Technology (B16790355 and A13307016), and the Korean Centers for Disease Control and Prevention (Government budget code 2004-347-6111-213).

Keywords

Atherosclerosis
Carotid Artery
Cohort Studies
Coronary Disease
Japanese
Koreans

ASJC Scopus subject areas

Epidemiology

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10.1016/j.annepidem.2007.08.002

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@article{4d7ee6647b744392902813778c36af60,

title = "Difference in Carotid Intima-Media Thickness Between Korean and Japanese Men",

abstract = "Purpose: Koreans are recently at higher risk for coronary heart disease than are the Japanese. We aimed to evaluate levels of carotid intima-media thickness (IMT) and coronary risk factors in Korean and Japanese men in the post-World War II birth cohort. Methods: We conducted a population-based study of 352 randomly selected healthy men 40 to 49 years of age: 102 Koreans in Ansan City, Gyeonggi-do, Korea and 250 Japanese in Kusatsu City, Shiga, Japan. Imaging carotid IMT by ultrasonography and other procedures were standardized. Analyzing blood samples and reading carotid IMT were performed at the University of Pittsburgh. Results: Despite more favorable or similar features in coronary risk factors as compared to Japanese men, the Korean men had a higher crude IMT level than the Japanese men (mean ± standard error, 0.655 ± 0.008 mm vs 0.616 ± 0.005 mm, respectively, p < 0.0001). The difference in the levels of carotid IMT significantly remained after adjusting for metabolic and conventional risk factors (0.654 ± 0.008 mm vs. 0.616 ± 0.005 mm, respectively; p < 0.0001). Conclusions: Among men 40 to 49 years of age, Koreans had significantly higher levels of carotid IMT than the Japanese. Factors that underlie the different susceptibility to subclinical atherosclerosis need to be explored.",

keywords = "Atherosclerosis, Carotid Artery, Cohort Studies, Coronary Disease, Japanese, Koreans",

author = "Jina Choo and Hirotsugu Ueshima and Yangsoo Jang and Kim Sutton-Tyrrell and Aiman El-Saed and Takashi Kadowaki and Tomoko Takamiya and Tomonori Okamura and Yoshiki Ueno and Yasuyuki Nakamura and Akira Sekikawa and Curb, {J. David} and Kuller, {Lewis H.} and Chol Shin",

note = "Funding Information: This research was supported by grants from the National Heart Lung and Blood Institute (R01 HL68200), the Central Research Development at the University of Pittsburgh, the Japanese Ministry of Education, Culture, Sports, Science and Technology (B16790355 and A13307016), and the Korean Centers for Disease Control and Prevention (Government budget code 2004-347-6111-213).",

year = "2008",

month = apr,

doi = "10.1016/j.annepidem.2007.08.002",

language = "English",

volume = "18",

pages = "310--315",

journal = "Annals of Epidemiology",

issn = "1047-2797",

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T1 - Difference in Carotid Intima-Media Thickness Between Korean and Japanese Men

AU - Choo, Jina

AU - Ueshima, Hirotsugu

AU - Jang, Yangsoo

AU - Sutton-Tyrrell, Kim

AU - El-Saed, Aiman

AU - Kadowaki, Takashi

AU - Takamiya, Tomoko

AU - Okamura, Tomonori

AU - Ueno, Yoshiki

AU - Nakamura, Yasuyuki

AU - Sekikawa, Akira

AU - Curb, J. David

AU - Kuller, Lewis H.

AU - Shin, Chol

N1 - Funding Information: This research was supported by grants from the National Heart Lung and Blood Institute (R01 HL68200), the Central Research Development at the University of Pittsburgh, the Japanese Ministry of Education, Culture, Sports, Science and Technology (B16790355 and A13307016), and the Korean Centers for Disease Control and Prevention (Government budget code 2004-347-6111-213).

PY - 2008/4

Y1 - 2008/4

N2 - Purpose: Koreans are recently at higher risk for coronary heart disease than are the Japanese. We aimed to evaluate levels of carotid intima-media thickness (IMT) and coronary risk factors in Korean and Japanese men in the post-World War II birth cohort. Methods: We conducted a population-based study of 352 randomly selected healthy men 40 to 49 years of age: 102 Koreans in Ansan City, Gyeonggi-do, Korea and 250 Japanese in Kusatsu City, Shiga, Japan. Imaging carotid IMT by ultrasonography and other procedures were standardized. Analyzing blood samples and reading carotid IMT were performed at the University of Pittsburgh. Results: Despite more favorable or similar features in coronary risk factors as compared to Japanese men, the Korean men had a higher crude IMT level than the Japanese men (mean ± standard error, 0.655 ± 0.008 mm vs 0.616 ± 0.005 mm, respectively, p < 0.0001). The difference in the levels of carotid IMT significantly remained after adjusting for metabolic and conventional risk factors (0.654 ± 0.008 mm vs. 0.616 ± 0.005 mm, respectively; p < 0.0001). Conclusions: Among men 40 to 49 years of age, Koreans had significantly higher levels of carotid IMT than the Japanese. Factors that underlie the different susceptibility to subclinical atherosclerosis need to be explored.

AB - Purpose: Koreans are recently at higher risk for coronary heart disease than are the Japanese. We aimed to evaluate levels of carotid intima-media thickness (IMT) and coronary risk factors in Korean and Japanese men in the post-World War II birth cohort. Methods: We conducted a population-based study of 352 randomly selected healthy men 40 to 49 years of age: 102 Koreans in Ansan City, Gyeonggi-do, Korea and 250 Japanese in Kusatsu City, Shiga, Japan. Imaging carotid IMT by ultrasonography and other procedures were standardized. Analyzing blood samples and reading carotid IMT were performed at the University of Pittsburgh. Results: Despite more favorable or similar features in coronary risk factors as compared to Japanese men, the Korean men had a higher crude IMT level than the Japanese men (mean ± standard error, 0.655 ± 0.008 mm vs 0.616 ± 0.005 mm, respectively, p < 0.0001). The difference in the levels of carotid IMT significantly remained after adjusting for metabolic and conventional risk factors (0.654 ± 0.008 mm vs. 0.616 ± 0.005 mm, respectively; p < 0.0001). Conclusions: Among men 40 to 49 years of age, Koreans had significantly higher levels of carotid IMT than the Japanese. Factors that underlie the different susceptibility to subclinical atherosclerosis need to be explored.

KW - Atherosclerosis

KW - Carotid Artery

KW - Cohort Studies

KW - Coronary Disease

KW - Japanese

KW - Koreans

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DO - 10.1016/j.annepidem.2007.08.002

M3 - Article

C2 - 17983767

AN - SCOPUS:41049096809

SN - 1047-2797

VL - 18

SP - 310

EP - 315

JO - Annals of Epidemiology

JF - Annals of Epidemiology

IS - 4

ER -

Difference in Carotid Intima-Media Thickness Between Korean and Japanese Men

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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