Differences in gray and white matter 18 F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias

Hye Joo Son, Jungsu S. Oh, Jee Hoon Roh, Sang Won Seo, Minyoung Oh, Sang Ju Lee, Seung Jun Oh, Jae Seung Kim

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Purpose: We investigated the regional distribution of 18 F-THK5351 uptake in gray (GM) and white matter (WM) in patients with behavioral-variant frontotemporal dementia (bvFTD) and compared it with that in patients with Alzheimer’s disease (AD) or semantic dementia (SD). Methods: 18 F-THK-5351 positron emission tomography (PET), 18 F-florbetaben PET, magnetic resonance imaging, and neuropsychological testing were performed in 103 subjects including 30, 24, 9, and 8 patients with mild cognitive impairment, AD, bvFTD, and SD, respectively, and 32 normal subjects. Standardized uptake value ratios (SUVRs) of 18 F-THK-5351 PET images were measured from six GM and WM regions using cerebellar GM as reference. GM and WM SUVRs and WM/GM ratios, the relationship between GM SUVR and WM/GM ratio, and correlation between SUVR and cognitive function were compared. Results: In AD, both parietal GM (p < 0.001) and WM (p < 0.001) SUVRs were higher than in bvFTD. In AD and SD, the WM/GM ratio decreased as the GM SUVR increased, regardless of lobar region. In AD, memory function correlated with parietal GM (ρ = −0.74, p < 0.001) and WM (ρ = −0.53, p < 0.001) SUVR. In SD, language function correlated with temporal GM SUVR (ρ = −0.69, p = 0.006). The frontal WM SUVR was higher in bvFTD than in AD (p = 0.003) or SD (p = 0.017). The frontal WM/GM ratio was higher in bvFTD than in AD (p < 0.001). In bvFTD, the WM/GM ratio increased more prominently than the GM SUVR only in the frontal lobe (R 2 = 0.026). In bvFTD, executive function correlated with frontal WM SUVR (ρ = −0.64, p = 0.014). Conclusions: Frontal WM 18 F-THK5351 uptake was higher in bvFTD than in other dementias. The increase in frontal WM uptake was greater than the increase in GM uptake and correlated with executive function. This suggests that frontal lobe WM 18 F-THK5351 uptake reflects neuropathological differences between bvFTD and other dementias.

Original languageEnglish
Pages (from-to)357-366
Number of pages10
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number2
Publication statusPublished - 2019 Feb 1
Externally publishedYes


  • F-THK-5351
  • Behavioral-variant frontotemporal dementia
  • PET
  • Tau
  • White matter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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