Different expression patterns of Phactr family members in normal and injured mouse brain

J. Y. Kim, S. Y. Choi, Y. Moon, H. J. Kim, J. H. Chin, H. Kim, W. Sun

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Phosphatase and actin regulators (Phactrs) are a novel family of proteins expressed in the brain, and they exhibit both strong modulatory activity of protein phosphatase 1 and actin-binding activity. Phactrs are comprised of four family members (Phactr1-4), but their detailed expression patterns during embryonic and postnatal development are not well understood. We found that these family members exhibit different spatiotemporal mRNA expression patterns. Phactr4 mRNA was found in neural stem cells in the developing and adult brains, whereas Phactr1 and 3 appeared to be expressed in post-mitotic neurons. Following traumatic brain injury which promotes neurogenesis in the neurogenic region and gliogenesis in the injury penumbra, the mRNA expression of phactr2 and 4 was progressively increased in the injury penumbra, and phactr4 mRNA and protein induction was observed in reactive astrocytes. These differential expression patterns of phactrs imply specific functions for each protein during development, and the importance of Phactr4 in the reactive gliosis following brain injury.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
Publication statusPublished - 2012 Sept 27

Bibliographical note

Funding Information:
This work is supported by Grants from the Korean Ministry of Education, Science, and Technology by Brain Research Center of the twenty-first century Frontier Program in Neuroscience (2011K000262; 2011K000288) and the National Research Foundation of Korea (20110019409).


  • In situ hybridization
  • Neural stem/progenitor cell
  • Phactrs
  • Traumatic brain injury

ASJC Scopus subject areas

  • General Neuroscience


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