Different radiological findings with the same pathologic diagnosis due to different age in primary osteosarcoma

S. Y. Lee, W. H. Cho, W. S. Song, J. H. Park

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Purpose: To examine the imaging characteristics of osteoblastic osteosarcoma in older patients, we compared them with those in adolescents because the radiological features of osteosarcoma can be atypical in elderly patients. Material and Methods: 29 cases of adolescent patients and 12 patients older than 40 years of age were reviewed. All cases were pathologically confirmed as osteoblastic osteosarcoma. The comparative factors were tumor location, plain radiological features including periosteal reactions, and the degree of soft tissue mass with magnetic resonance (MR) imaging. Results: Older patients demonstrated frequent osteolytic findings (83.3%), and none of the tumors showed a significant major periosteal reaction. Seven (58.3%) of the 12 tumors had no soft tissue mass (grade 0) and only three (25%) had a grade 3 mass. The differences in the two groups were statistically significant (P<0.001). Conclusion: In older patients, primary osteosarcoma should be considered when making a differential diagnosis of osteolytic lesions without any periosteal reactions and small soft-tissue extensions. In cases with atypical findings, the morphology of specimens (aspiration, core, or surgical biopsy) from the lesion should be recommended when making an accurate diagnosis.

Original languageEnglish
Pages (from-to)841-844
Number of pages4
JournalActa Radiologica
Issue number8
Publication statusPublished - 2006 Oct 1
Externally publishedYes


  • Older age
  • Primary osteoblastic osteosarcoma
  • Radiological findings

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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