Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype

Junhu Tai, Jiwon Kwak, Munsoo Han, Tae Hoon Kim

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical dysfunction caused by an abnormal remodeling process. Recent studies have shown that an increase in DCs in CRS and their function of shaping the nasal mucosal immune response may play an important role in the pathogenesis of CRS. In this review, we discuss DC subsets in mice and humans, as well as the function of DCs in the nasal sinus mucosa. In addition, the mechanism by which DCs can be used as targets for therapeutic intervention for CRS and potential future research directions are also discussed.

Original languageEnglish
Article number8032
JournalInternational journal of molecular sciences
Volume23
Issue number14
DOIs
Publication statusPublished - 2022 Jul

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and the Ministry of Science, ICT and Future Planning (2017R1A2B2003575 and NRF-2020R1A2C1006398); the Ministry of Science and ICT, Korea, under the ICT Creative Consilience program (IITP-2022-2020-0-01819), supervised by the Institute for Information and Communications Technology Planning and Evaluation (IITP); and the Korea Health Technology R&D Project (HI17C0387, HI22C1302) through Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare. This research was also supported by a Korea University grant and a grant from the Korea University Medical Center and Anam Hospital in Seoul, Republic of Korea.

Publisher Copyright:
© 2022 by the authors.

Keywords

  • chronic rhinosinusitis
  • dendritic cells
  • immunity
  • phenotype

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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