Differential modification of enalapril in the kidneys of lean and 'programmed' obese male young rats

Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong, Joo Won Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective We investigated whether enalapril treatment could have beneficial effects on nutritionally-programmed renal changes in postnatally overfed young rats. Methods Three or 10 male pups per mother were assigned to either the Obese or Lean groups during the first 21 days of life. These pups were treated with enalapril (Obese enalapril, OE; Lean enalapril, LE) or vehicle (Obese control, OC; Lean control, LC) between 15 and 28 days. All pups had their kidneys examined at 29 days. Results OC pups weighed more than those in the LC group between 7 and 28 days of age (P < 0.05). Enalapril reduced body weights in rats from both the Obese and Lean groups between 22 and 28 days (P < 0.05). Renal cell proliferation and apoptosis, glomerulosclerosis, and tubulointerstitial fibrosis were all increased by enalapril (P < 0.05). Among the groups, renal cell apoptosis and serum creatinine were the highest in OE pups (P < 0.05). Enalapril treatment resulted in contrasting molecular expression profiles involved in renal maturation and repair in the kidneys of the rats from the Lean and Obese groups. Conclusion Enalapril can differentially modulate renal molecular alterations in lean and postnatally overfed rats and may be not beneficial in obese young male rats.

Original languageEnglish
Pages (from-to)281-292
Number of pages12
JournalObesity Research and Clinical Practice
Issue number3
Publication statusPublished - 2015 May 1
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 20120002191 ).

Publisher Copyright:
© 2015 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.


  • Angiotensin II
  • Extracellular matrix
  • Growth and development
  • Overnutrition
  • Regeneration

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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