TY - JOUR
T1 - Differentiation of hepatocellular carcinoma from its various mimickers in liver magnetic resonance imaging
T2 - What are the tips when using hepatocyte-specific agents?
AU - Park, Yang Shin
AU - Lee, Chang Hee
AU - Kim, Jeong Woo
AU - Shin, Sora
AU - Park, Cheol Min
N1 - Publisher Copyright:
© The Author(s) 2016.
PY - 2016/1/7
Y1 - 2016/1/7
N2 - Hepatocellular carcinoma is the most common primary hepatic malignant tumor. With widespread use of liver imaging, various cirrhosis-related nodules are frequently detected in patients with chronic liver disease, while diverse hypervascular hepatic lesions are incidentally detected but undiagnosed on dynamic computed tomography and magnetic resonance imaging (MRI). However, use of hepatocyte-specific MR contrast agents with combined perfusion and hepatocyte-selective properties have improved diagnostic performance in detection and characterization of focal liver lesions. Meanwhile, the enhancement patterns observed during dynamic phases using hepatocyte-specific agents may be different from those observed during MRI using conventional extracellular fluid agents, leading to confusion in diagnosis. Therefore, we discuss useful tips for the differentiation of hepatocellular carcinoma from similar lesions in patients with and without chronic liver disease using liver MRI with hepatocyte-specific agents.
AB - Hepatocellular carcinoma is the most common primary hepatic malignant tumor. With widespread use of liver imaging, various cirrhosis-related nodules are frequently detected in patients with chronic liver disease, while diverse hypervascular hepatic lesions are incidentally detected but undiagnosed on dynamic computed tomography and magnetic resonance imaging (MRI). However, use of hepatocyte-specific MR contrast agents with combined perfusion and hepatocyte-selective properties have improved diagnostic performance in detection and characterization of focal liver lesions. Meanwhile, the enhancement patterns observed during dynamic phases using hepatocyte-specific agents may be different from those observed during MRI using conventional extracellular fluid agents, leading to confusion in diagnosis. Therefore, we discuss useful tips for the differentiation of hepatocellular carcinoma from similar lesions in patients with and without chronic liver disease using liver MRI with hepatocyte-specific agents.
KW - Gadoxetic acid
KW - Hepatocellular carcinoma
KW - Liver cirrhosis
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=84953439251&partnerID=8YFLogxK
U2 - 10.3748/wjg.v22.i1.284
DO - 10.3748/wjg.v22.i1.284
M3 - Article
C2 - 26755877
AN - SCOPUS:84953439251
SN - 1007-9327
VL - 22
SP - 284
EP - 299
JO - World journal of gastroenterology
JF - World journal of gastroenterology
IS - 1
ER -