Diffusion tensor image registration using hybrid connectivity and tensor features

Qian Wang, Pew Thian Yap, Guorong Wu, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Most existing diffusion tensor imaging (DTI) registration methods estimate structural correspondences based on voxelwise matching of tensors. The rich connectivity information that is given by DTI, however, is often neglected. In this article, we propose to integrate complementary information given by connectivity features and tensor features for improved registration accuracy. To utilize connectivity information, we place multiple anchors representing different brain anatomies in the image space, and define the connectivity features for each voxel as the geodesic distances from all anchors to the voxel under consideration. The geodesic distance, which is computed in relation to the tensor field, encapsulates information of brain connectivity. We also extract tensor features for every voxel to reflect the local statistics of tensors in its neighborhood. We then combine both connectivity features and tensor features for registration of tensor images. From the images, landmarks are selected automatically and their correspondences are determined based on their connectivity and tensor feature vectors. The deformation field that deforms one tensor image to the other is iteratively estimated and optimized according to the landmarks and their associated correspondences. Experimental results show that, by using connectivity features and tensor features simultaneously, registration accuracy is increased substantially compared with the cases using either type of features alone. Hum Brain Mapp 35:3529-3546, 2014.

Original languageEnglish
Pages (from-to)3529-3546
Number of pages18
JournalHuman Brain Mapping
Issue number7
Publication statusPublished - 2014 Jul


  • Connectivity features
  • Correspondence detection
  • Diffusion tensor image registration
  • Tensor features

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Diffusion tensor image registration using hybrid connectivity and tensor features'. Together they form a unique fingerprint.

Cite this