Digitally tunable physicochemical coding of material composition and topography in continuous microfibres

Edward Kang; Gi Seok Jeong; Yoon Young Choi; Kwang Ho Lee; Ali Khademhosseini; Sang Hoon Lee

doi:10.1038/nmat3108

Digitally tunable physicochemical coding of material composition and topography in continuous microfibres

Edward Kang, Gi Seok Jeong, Yoon Young Choi, Kwang Ho Lee, Ali Khademhosseini, Sang Hoon Lee

Research output: Contribution to journal › Article › peer-review

424 Citations (Scopus)

Abstract

Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro-or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro-bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.

Original language	English
Pages (from-to)	877-883
Number of pages	7
Journal	Nature Materials
Volume	10
Issue number	11
DOIs	https://doi.org/10.1038/nmat3108
Publication status	Published - 2011 Nov

Bibliographical note

Funding Information:
This study was supported by a grant from the NRL (National Research Laboratory) programme, the Korea Science and Engineering Foundation (KOSEF), Republic of Korea (No. 20110020455), basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. R11-2008-044-02002-0) and the Korea Research and Engineering Foundation (KOSEF) funded by the Korea government (KRF; No. KRF-2008-220-D00133).

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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title = "Digitally tunable physicochemical coding of material composition and topography in continuous microfibres",

abstract = "Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro-or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro-bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.",

author = "Edward Kang and Jeong, {Gi Seok} and Choi, {Yoon Young} and Lee, {Kwang Ho} and Ali Khademhosseini and Lee, {Sang Hoon}",

note = "Funding Information: This study was supported by a grant from the NRL (National Research Laboratory) programme, the Korea Science and Engineering Foundation (KOSEF), Republic of Korea (No. 20110020455), basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. R11-2008-044-02002-0) and the Korea Research and Engineering Foundation (KOSEF) funded by the Korea government (KRF; No. KRF-2008-220-D00133).",

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doi = "10.1038/nmat3108",

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AU - Jeong, Gi Seok

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AU - Khademhosseini, Ali

AU - Lee, Sang Hoon

N1 - Funding Information: This study was supported by a grant from the NRL (National Research Laboratory) programme, the Korea Science and Engineering Foundation (KOSEF), Republic of Korea (No. 20110020455), basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. R11-2008-044-02002-0) and the Korea Research and Engineering Foundation (KOSEF) funded by the Korea government (KRF; No. KRF-2008-220-D00133).

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AB - Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro-or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro-bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.

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Digitally tunable physicochemical coding of material composition and topography in continuous microfibres

Abstract

Bibliographical note

ASJC Scopus subject areas

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