Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica

Qinghao Jin, Jin Woo Lee, Hari Jang, Hye Lim Lee, Jun Gu Kim, Wanying Wu, Dongho Lee, Eun Hee Kim, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


An undescribed unusual sesquiterpene trimer and three sesquiterpene dimers were isolated from the flowers of Inula japonica. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data as well as HRESIMS data. Inulajaponicolide A has an undescribed carbon skeleton comprising of one xanthanolide and two guaianolide units with the linkage mode of C-11/C-3ʹ and C-11ʹ/C-1ʹʹ via a Diels-Alder cycloaddition reaction. Inulajaponicolides C and D exhibited moderate cytotoxic activity against A 549 and NCI-H460 human cancer cell lines with IC50 values ranging from 8.5 to 17.8 μM. Inulajaponicolides A-D and lineariifolianoid A possessed significant inhibitory potency against nitric oxide production in LPS-induced RAW264.7 cells with IC50 values ranging from 1.0 to 4.1 μM.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
Publication statusPublished - 2018 Nov

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd


  • Asteraceae
  • Cytotoxic activity
  • Inula japonica
  • Nitric oxide
  • Sesquiterpene trimer
  • Sesquiterpenes dimer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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