Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius

Qinghao Jin; Jin Woo Lee; Hari Jang; Ji Eun Choi; Hyung Sik Kim; Dongho Lee; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2016.10.017

Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius

Qinghao Jin, Jin Woo Lee, Hari Jang, Ji Eun Choi, Hyung Sik Kim, Dongho Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3–8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (¹H and¹³C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.

Original language	English
Pages (from-to)	5995-5998
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2016.10.017
Publication status	Published - 2016

Bibliographical note

Funding Information:
This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275 ) through the National Research Foundation of Korea .

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Anti-inflammatory
Asteraceae
Dimeric sesquiterpene
Echinops latifolius
Thiophene

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2016.10.017

Cite this

@article{3450fdfec72744ef87607b173b8b45fa,

title = "Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius",

abstract = "Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3–8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (1H and13C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.",

keywords = "Anti-inflammatory, Asteraceae, Dimeric sesquiterpene, Echinops latifolius, Thiophene",

author = "Qinghao Jin and Lee, {Jin Woo} and Hari Jang and Choi, {Ji Eun} and Kim, {Hyung Sik} and Dongho Lee and Hong, {Jin Tae} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

note = "Funding Information: This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275 ) through the National Research Foundation of Korea . Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

doi = "10.1016/j.bmcl.2016.10.017",

language = "English",

volume = "26",

pages = "5995--5998",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "24",

}

TY - JOUR

T1 - Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius

AU - Jin, Qinghao

AU - Lee, Jin Woo

AU - Jang, Hari

AU - Choi, Ji Eun

AU - Kim, Hyung Sik

AU - Lee, Dongho

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

N1 - Funding Information: This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275 ) through the National Research Foundation of Korea . Publisher Copyright: © 2016 Elsevier Ltd

PY - 2016

Y1 - 2016

N2 - Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3–8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (1H and13C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.

AB - Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3–8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (1H and13C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.

KW - Anti-inflammatory

KW - Asteraceae

KW - Dimeric sesquiterpene

KW - Echinops latifolius

KW - Thiophene

UR - http://www.scopus.com/inward/record.url?scp=84999040112&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2016.10.017

DO - 10.1016/j.bmcl.2016.10.017

M3 - Article

C2 - 27865705

AN - SCOPUS:84999040112

SN - 0960-894X

VL - 26

SP - 5995

EP - 5998

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this