Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius

Qinghao Jin, Jin Woo Lee, Hari Jang, Ji Eun Choi, Hyung Sik Kim, Dongho Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3–8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (1H and13C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.

Original languageEnglish
Pages (from-to)5995-5998
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number24
Publication statusPublished - 2016

Bibliographical note

Funding Information:
This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275 ) through the National Research Foundation of Korea .

Publisher Copyright:
© 2016 Elsevier Ltd


  • Anti-inflammatory
  • Asteraceae
  • Dimeric sesquiterpene
  • Echinops latifolius
  • Thiophene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


Dive into the research topics of 'Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius'. Together they form a unique fingerprint.

Cite this