Direct fabrication of enzyme-carrying polymer nanofibers by electrospinning

Thurston E. Herricks, Sae Hoon Kim, Jungbae Kim, Dan Li, Ja Hun Kwak, Jay W. Grate, Seong H. Kim, Younan Xia

Research output: Contribution to journalArticlepeer-review

112 Citations (Scopus)


Nanofibers consisting of enzyme-polymer composites have been prepared by directly electrospinning a solution of surfactant-stabilized enzyme and polymer in toluene. Additional treatment with glutaraldehyde could greatly stabilize the enzyme activity of the fibers, which could be maintained in a buffer under shaking conditions for more than two weeks. The nanofibers also showed great improvement in the enzyme activity over bulk films as a result of increased mass-transfer for substrate molecules to and from the enzyme reactive sites. These stable and catalytically active nanofiber-based mats were highly durable and could be easily recovered from solution, making them ideal candidates for large scale applications.

Original languageEnglish
Pages (from-to)3241-3245
Number of pages5
JournalJournal of Materials Chemistry
Issue number31
Publication statusPublished - 2005 Aug 21
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry


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