Directing stem cell differentiation by changing the molecular mobility of supramolecular surfaces

Ji Hun Seo; Sachiro Kakinoki; Tetsuji Yamaoka; Nobuhiko Yui

doi:10.1002/adhm.201400173

Directing stem cell differentiation by changing the molecular mobility of supramolecular surfaces

Ji Hun Seo, Sachiro Kakinoki, Tetsuji Yamaoka, Nobuhiko Yui

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Polymer surfaces with a wide range of hydrated surface mobility are developed by a simple deposition method with supramolecular block copolymers. The morphologies of adhering stem cells are greatly dependent on the surface mobility of polymers, and this induces significant changes in the cytoskeletal signaling pathway to direct the downstream stem cell differentiation.

Original language	English
Pages (from-to)	215-222
Number of pages	8
Journal	Advanced Healthcare Materials
Volume	4
Issue number	2
DOIs	https://doi.org/10.1002/adhm.201400173
Publication status	Published - 2015 Jan 1
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Mesenchymal stem cells
PCR
Polyrotaxane
QCM-D
Supramolecules

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.201400173

Cite this

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abstract = "Polymer surfaces with a wide range of hydrated surface mobility are developed by a simple deposition method with supramolecular block copolymers. The morphologies of adhering stem cells are greatly dependent on the surface mobility of polymers, and this induces significant changes in the cytoskeletal signaling pathway to direct the downstream stem cell differentiation.",

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KW - PCR

KW - Polyrotaxane

KW - QCM-D

KW - Supramolecules

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Directing stem cell differentiation by changing the molecular mobility of supramolecular surfaces

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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