Discoid lupus erythematosus-like eruption induced by tegafur - Uracil (UFT)

Junghee Yoon, Soo Hong Seo, Young Chul Kye, Hyo Hyun Ahn

    Research output: Contribution to journalArticlepeer-review


    The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows a higher 5-FU concentration in the tumor tissues than is achieved by tegafur alone or with comparable doses of intravenous 5-FU. Mucocutaneous side reactions induced by UFT are rare and these include photosensitivity of the lichenoid and eczematous types, acral erythema, hyperpigmentation, palmoplantar keratoderma and scleroderma-like reactions, and discoid lupus erythematosus (DLE)-like eruption. However, there has been no report in the Korean medical literature on patients presenting with a DLE-like eruption associated with UFT. So, we report here a case of DLE-like eruption induced by oral UFT.

    Original languageEnglish
    Pages (from-to)1004-1007
    Number of pages4
    JournalKorean Journal of Dermatology
    Issue number11
    Publication statusPublished - 2010 Nov


    • Discoid lupus erythematosus
    • Tegafur
    • UFT

    ASJC Scopus subject areas

    • Dermatology


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