Discovery of dioxo-benzo[b]thiophene derivatives as potent YAP-TEAD interaction inhibitors for treating breast cancer

Keyphrases

• Yes-associated Protein 1 (YAP1) 100%
• Breast Cancer 100%
• Benzo 100%
• Dioxo 100%
• Thiophene Derivatives 100%
• Domain-domain Interaction 100%
• Solid Tumors 33%
• Amide Derivatives 33%
• Transcription Factor 16%
• Synthesized Compounds 16%
• Therapeutic Agents 16%
• Overexpressing 16%
• Coactivator 16%
• High Potency 16%
• IC50 16%
• Protein-protein Interaction 16%
• Transcriptional Enhancer 16%
• Potential Therapeutic Strategies 16%
• Transcriptional Coactivator with PDZ-binding Motif 16%
• Breast Cancer Cells 16%
• Proteinase Inhibitor 16%
• Thiophene 16%
• Hit Compound 16%
• GI50 16%
• Cancer Cell Growth 16%
• Anchorage-independent Growth 16%
• Soft Agar 16%
• Expression Activity 16%
• Isothiazole 16%
• Cyr61 16%
• Compound 8 16%
• Molecular Docking Analysis 16%
• Reporter Expression 16%
• Docking Score 16%
• Hydrazone Derivatives 16%
• Oxime Ester 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Breast Cancer 100%
• Carboxamide 100%
• Solid Malignant Neoplasm 100%
• Benzothiophene Derivative 100%
• IC50 50%
• Transcription Factors 50%
• Connective Tissue Growth Factor 50%
• Oxime 50%
• Cancer Growth 50%
• Agar 50%
• Benzothiophene 50%
• Isothiazole 50%
• Hydrazone Derivative 50%

Biochemistry, Genetics and Molecular Biology

• Benzothiophene 100%
• Transcription Factors 50%
• Cancer Cell 50%
• Cell Growth 50%
• IC50 50%
• Protein Interaction 50%
• Enhancer Region 50%
• Connective Tissue Growth Factor 50%
• Agar 50%
• Anchorage Independent Growth 50%
• Docking (Molecular) 50%
• CYR61 50%
• Isothiazole 50%
• GI50 50%