Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects

Chung Ju, Sumi Song, Sunyoung Hwang, Chorong Kim, Minkyoung Kim, Jail Gu, Yu Kyoung Oh, Kyeong Lee, Jinsun Kwon, Kiho Lee, Won Ki Kim, Yongseok Choi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-d-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-d-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.

Original languageEnglish
Pages (from-to)5421-5425
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
Publication statusPublished - 2013 Oct 1

Bibliographical note

Funding Information:
This research was supported by the Korea Health Technology R&D Project, the Ministry of Health & Welfare ( #A100766 to W.-K.K.) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( #2011-0026325 to Y.C.), Republic of Korea. We are grateful to Dr. In-Young Choi for helpful scientific information regarding (S)-cis-verbenol and Dr. Paul L. Prather (University of Arkansas) for careful reading.


  • Anti-excitotoxic activity
  • Anti-ischemic activity
  • Anti-oxidant activity
  • Cerebral ischemia
  • Verbenone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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