Abstract
A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-d-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-d-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.
Original language | English |
---|---|
Pages (from-to) | 5421-5425 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 23 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2013 Oct 1 |
Bibliographical note
Funding Information:This research was supported by the Korea Health Technology R&D Project, the Ministry of Health & Welfare ( #A100766 to W.-K.K.) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( #2011-0026325 to Y.C.), Republic of Korea. We are grateful to Dr. In-Young Choi for helpful scientific information regarding (S)-cis-verbenol and Dr. Paul L. Prather (University of Arkansas) for careful reading.
Keywords
- Anti-excitotoxic activity
- Anti-ischemic activity
- Anti-oxidant activity
- Cerebral ischemia
- Verbenone
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry